| IED ID | IndEnz0002007100 |
| Enzyme Type ID | protease007100 |
| Protein Name |
Aspartic-type endopeptidase ctsD EC 3.4.23.- |
| Gene Name | ctsD AFUA_4G07040 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MHLLQCLLSTISLASTVTAFVPYSFNLEVSTEGPPSNDVARRFVPWKLLLDDSYNNHGSSSNGVSLTLDLKKFPVRRDNKYKVVLADEPTTPNTAALNQEGLDYSYFATVRVGSQGQQMWLVLDTGGPNTWVFGSDCTTVACQRHETFGEAASKSLKLLPLNWAVGYGTGLVSGVLGTDSLSLAGLDVNMTFGLAKNASTDFESYPVDGILGLGRSANSNFNTPSFMETVATQRLLKSNIIGFSFSRNSDGARDGAANFGDLDTTRFTGDIVYTNTTGDSNNWRIPLDDASVNGTPCRFVNKTAVIDTGTSYAMLPPKDATVLHNLIPGAVTTSHGQNFTLPCNSTAVVQVSFSGLSYNISPKDYVGPAYGSACLSTIVGQALYGDDVWLLGDVFLKNVYSVFDYDNHRIGFANRSVPIASPTTTVAAAANPSATDGAGSTLTGSMAVHTGSASIVSRFVHWPFIFALLCMVLV |
| Enzyme Length | 474 |
| Uniprot Accession Number | Q4WNV0 |
| Absorption | |
| Active Site | ACT_SITE 124; /evidence=ECO:0000250; ACT_SITE 307; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Secreted aspartic-type endopeptidase which is secreted and contributes to virulence. {ECO:0000269|PubMed:17275325}. |
| Temperature Dependency | |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 5.0. {ECO:0000269|PubMed:17275325}; |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Glycosylation (7); Lipidation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Cell membrane;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Signal;Virulence |
| Interact With | |
| Induction | INDUCTION: Repressed under nutrient-rich culture conditions. {ECO:0000269|PubMed:17275325}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 50,548 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |