| IED ID | IndEnz0002007120 |
| Enzyme Type ID | protease007120 |
| Protein Name |
Cysteine proteinase 1 EC 3.4.22.- |
| Gene Name | CPP1 CPP |
| Organism | Entamoeba histolytica |
| Taxonomic Lineage | cellular organisms Eukaryota Amoebozoa Evosea Archamoebae Mastigamoebida Entamoebidae Entamoeba Entamoeba histolytica |
| Enzyme Sequence | MFTFILMFYIGYGIDFNTWVANNNKHFTAVESLRRRAIFNMNARIVAENNRKETFKLSVDGPFAAMTNEEYNSLLKLKRSGEEKGEVRYLNIQAPKAVDWRKKGKVTPIRDQGNCGSCYTFGSIAALEGRLLIEKGGDSETLDLSEEHMVQCTREDGNNGCNGGLGSNVYNYIMENGIAKESDYPYTGSDSTCRSDVKAFAKIKSYNRVARNNEVELKAAISQGLVDVSIDASSVQFQLYKSGAYTDTQCKNNYFALNHEVCAVGYGVVDGKECWIVRNSWGTGWGEKGYINMVIEGNTCGVATDPLYPTGVEYL |
| Enzyme Length | 315 |
| Uniprot Accession Number | Q01957 |
| Absorption | |
| Active Site | ACT_SITE 118; /evidence=ECO:0000250; ACT_SITE 259; /evidence=ECO:0000250; ACT_SITE 279; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in the destruction of human tissue by E.histolytica. Can abolish adhesion and degrade matrix proteins such as collagen, laminin and fibronectin. May play an important role in pathogenicity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (2); Propeptide (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Signal;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..13; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 35,056 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.22.35; |