| IED ID | IndEnz0002007193 |
| Enzyme Type ID | protease007193 |
| Protein Name |
Protein DDI1 homolog 1 EC 3.4.23.- |
| Gene Name | ddi-1 C01G5.6 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSFQVSVAVNDGPFQKKSVTPNTTIGDLNNDAILIWKDTAIVYDISDESKNFGPTVTLEQLGVTQISMVYIYTTAFPCPSGDLRSIVPAQVRLISQFASAASSIFNGQSSSSAQSAQRTRRVEQDDEGEKSMFSRKLLDSPATFKALSENMFFRLKNEPHKLGYGLPELVERFLAKKDMTYKEFEQMFRSYVEEEVHKEEIIKNNPNSAEAKMFLEAKRNKELIDEQYLHSMTHHPEDMIAVTMLYINLTINGVPVKAFIDSGAQKSIMSMACAERCGLNGLIDRRFQSMARGVGGTEKIEGKIHLCDVKVEDAHFSCPFEVMARREMDLLIGLNVLRKHGCCINLKTSRLEFGNGTTTPFLQSNEIDSHLKEIMALPEEEMQFEDGST |
| Enzyme Length | 389 |
| Uniprot Accession Number | Q17569 |
| Absorption | |
| Active Site | ACT_SITE 261; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3. {ECO:0000269|PubMed:27528192}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Mutagenesis (6); Region (1) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Nucleus;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27528192}. Nucleus {ECO:0000269|PubMed:27528192}. Note=Mainly localizes to the nucleus during proteasomal disruption. {ECO:0000269|PubMed:27528192}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11778048; 12679813; 19123269; 21177967; 21367940; 21841763; 22560298; 23800452; 25487147; 26912668; 30140741; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,716 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |