| IED ID | IndEnz0002007206 |
| Enzyme Type ID | protease007206 |
| Protein Name |
F-box/SPRY domain-containing protein 1 F-box synaptic protein 1 |
| Gene Name | fsn-1 CBG18196 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MTENNEETIVPDEQCNLTSSTPMKSSDLENVESPIERKISIVECDGEGNPPIESSEETPPDLTSHSVAPRRRRSPRRPEVSASRLPLKVLNQIFQYLSLKDLRSAMLTCHSWNNALSMEDSDIWQQLLVQKLPEAAHSDPFLFVELRSARKKLRAWYFAWNTNDISRNNYIRTNGFTVHRQPVAQSTDGVRGKRGVSQGVHAFDITWDGPLGTVAVVGFATKHAALHCVGYIALLGSDDQSWGWNLVDNVLMHNGVQLGVYPKMNNPPKYEVGEKIRLVIDCDMHVAYFERNSEFLGIAFSHIPPLRLFPAVCAVYGNTEVTMVYVGSPQMG |
| Enzyme Length | 332 |
| Uniprot Accession Number | A8XT88 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf-2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM and ALM neurons. {ECO:0000250|UniProtKB:Q18223}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein ubiquitination. |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (2); Region (1) |
| Keywords | Cell junction;Reference proteome;Synapse;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 37,225 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |