| IED ID | IndEnz0002007267 |
| Enzyme Type ID | protease007267 |
| Protein Name |
Metacaspase-1B EC 3.4.22.- |
| Gene Name | casB AFUA_3G14140 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MYHRHSAPPPPGWSGGYPPRQQQWPPPQPYEYPPYPPQGPPPAHTFPPPAHRDYPSPYPTPPPHSPSPYQHPHHGHSQSWSVPAVPPRPPLEAQQFGNGAPSHYRFQYSACTGRRRALLIGINYIGQPNQLRGCINDVTNMSTFLHERYGYRREDMVILTDDQKNPLSIPTKANILRAMQWLVKDAQPNDSLFLHFSGHGGRTPDLDGDEEDGYDDVIYPVDYRVAGHIVDDEMHNIMVRPLRPGVRLTVIFDSCHSGTALDLPYVYSTQGILKEPNLAKEAAQDLFSAISSYGKGDLSGVAMTAIGFLKKAAKGDSARQRTVMTKTSPADVVMFSGSKDTQTSADTFQDGEARGALSWAFIKSLKQWPNQSYLQLLNSIRAQLDGKYTQKPQLSCSHPLDVNLLFVM |
| Enzyme Length | 408 |
| Uniprot Accession Number | Q4WYT0 |
| Absorption | |
| Active Site | ACT_SITE 199; /evidence=ECO:0000250; ACT_SITE 255; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in cell death (apoptosis) (By similarity). Required for the apoptotic-like loss of membrane phospholipid asymmetry at stationary phase and facilitates growth under conditions of endoplasmic reticulum stress. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Erroneous gene model prediction (1); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,473 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |