| IED ID | IndEnz0002007283 |
| Enzyme Type ID | protease007283 |
| Protein Name |
Calpain-like protease palB EC 3.4.22.- Cysteine protease palB |
| Gene Name | palB AN0256 |
| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Nidulantes Emericella nidulans (Aspergillus nidulans) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Enzyme Sequence | MSRTSSAPSQKSLISRALKAERDVITASSQSQALDAAIDAAEHYMKALALTSSSKDRNVLDAKCKEWLTRAEKIKGSEDWRSVAQSRRSRLRTPASTRKLTTREDIILLQGAKLNGFIFPPWKAEPSLTEFETGTNGDVLFTDKPDLHLSNLQRDIFAGWKRPHELLSGQVDDAGMPLNPVMTVSGNTDLVQDVLTDCSVVASLCATTSRSERGLDDTLLPIVYPCIHNSMKSDISPSGKYIFRFYFNGCFRKVVIDDRLPSSKTSRSLYMIDRNHRNFMWPALVEKAYLKLRGGYEFPGSNSGTDLWVLTGWIPEQVFLHSDEVTADQIWSDLFKSFHSGDVLLTIGTGKLTEREQKELGLVSEHDYAILDMKELKGRRQFLIKNPWAGTDAVYPALFADPGPFPNSPFLSPGTFWMDCEMVLQNFENLYLNWNPGIFAYQEDIHFTWDLSTGKGMAGCFVKNPQFSVYTERGGVVWLLLGRHLRTIESRASEEDERFGFISIYVFKGGKRVALSDGALHRGPYVDSPNTLMKLDVPPRSTYTAVVSEESLPRVSQNFTISAFSDSPVRISHAPNKYICVTKVQGSWTPTTAGGNAESARYSLNPQFSIVLSDPTDISIVLEPSDQELATHVKLFWSGGKRIARVRSRDIVADSGDYRRGGSLVEKQDLDPGEYTIVVSTFAPDQYGSFTLWVSTNITCEVTQLPSEAAGRRAVLSDIGVLLPGQDRMLAPLTTPRLTRVKLIARSRESRIGNRPVGPSPLLMTVELGQGPYKEILATSEDGDHSDSISGVRVEDFDLQPGLEERGGVWIVLERIGGPGGQVEDHFEVEALGEERVEIGEWIVEDA |
| Enzyme Length | 847 |
| Uniprot Accession Number | Q00204 |
| Absorption | |
| Active Site | ACT_SITE 198; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239; ACT_SITE 366; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239; ACT_SITE 386; /evidence=ECO:0000255|PROSITE-ProRule:PRU00239 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Required for the proteolytic cleavage of the transcription factor pacC in response to alkaline ambient pH. Probably is the signaling protease that mediates the first proteolytic cleavage within the signaling protease box of pacC, yielding the 53 kDa 'open' conformation intermediate protein, which is committed to further processing. Required for virulence in invasive pulmonary aspergillosis (IPA). {ECO:0000269|PubMed:15686555, ECO:0000269|PubMed:3016485, ECO:0000269|PubMed:7499363}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (2) |
| Keywords | Hydrolase;Protease;Reference proteome;Thiol protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 94,129 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |