| IED ID | IndEnz0002007290 |
| Enzyme Type ID | protease007290 |
| Protein Name |
Pyroglutamyl-peptidase 1 EC 3.4.19.3 5-oxoprolyl-peptidase Pyroglutamyl aminopeptidase I PAP-I Pyroglutamyl-peptidase I PGP-I Pyrrolidone-carboxylate peptidase |
| Gene Name | PGPEP1 PGPI |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MEQPRKAVVVTGFGPFGEHTVNASWIAVQELEKLGLGDSVDLHVYEIPVEYQTVQRLIPALWEKHSPQLVVHVGVSGMATTVTLEKCGHNKGYKGLDNCRFCPGSQCCVEDGPESIDSIIDMDAVCKRVTTLGLDVSVTISQDAGRYLCDFTYYTSLYQSHGRSAFVHVPPLGKPYNADQLGRALRAIIEEMLDLLEQSEGKINYCHKH |
| Enzyme Length | 209 |
| Uniprot Accession Number | Q9NXJ5 |
| Absorption | |
| Active Site | ACT_SITE 85; /evidence=ECO:0000250; ACT_SITE 149; /evidence=ECO:0000250; ACT_SITE 168; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by transition metal ions including Ni(2+), Zn(2+), and Cu(2+) and by sulfhydryl-blocking agents. {ECO:0000269|PubMed:12651114}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.; EC=3.4.19.3; Evidence={ECO:0000255|PROSITE-ProRule:PRU10076, ECO:0000255|PROSITE-ProRule:PRU10077, ECO:0000269|PubMed:12651114}; |
| DNA Binding | |
| EC Number | 3.4.19.3 |
| Enzyme Function | FUNCTION: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. {ECO:0000269|PubMed:12651114}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Alternative sequence (1); Chain (1) |
| Keywords | Alternative splicing;Cytoplasm;Hydrolase;Protease;Reference proteome;Thiol protease |
| Interact With | P29972; Q96HA8; Q96LR5; Q969T4 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15014037; 15380924; 20379614; 25687677; 26078706; 34816269; |
| Motif | |
| Gene Encoded By | |
| Mass | 23,138 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.19.3; |