| IED ID | IndEnz0002007314 |
| Enzyme Type ID | protease007314 |
| Protein Name |
Lon protease homolog, mitochondrial EC 3.4.21.53 |
| Gene Name | LON2 |
| Organism | Zea mays (Maize) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae PACMAD clade Panicoideae Andropogonodae Andropogoneae Tripsacinae Zea Zea mays (Maize) |
| Enzyme Sequence | MLRAAVAAAEELRSPLLRVIGTLRDGRGSVLLGRRVRFCSNSSASDTEAAVAEAEAKAEDASAAEGEADSKASSAIVPTSTNIDDCLSVIALPLPHRPLFPGFYMPINVKDQKLLQALIENRKRSAPYAGAFLVKDEEGTDPNIVTGSDSAKSIDDLKGKDLLKRLHEVGTLAQITSIQGDHVVLLGHRRLRITEMVEEDPLTVKVDHLKEKPYNKDDDVMKATSFEVISTLREVLRTSSLWKDHVQTYTQHIGDFNYQRLADFGAAISGANKLLCQEVLEELDVYKRLKLTLELVKKEMEISKLQQSIAKAIEEKISGDQRRYLLNEQLKAIKKELGLETDDKTALSAKFRERIESKKDKCPPHVLQVIEEELTKLQLLEASSSEFSVTRNYLDWLTVLPWGNYSDENFDVHHAQKILDEDHYGLSDVKERILEFIAVGKLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRQFYRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGKGHSGDPASALLELLDPEQNVNFLDHYLDVPIDLSKVLFVCTANVIEMIPNPLLDRMEIIAIAGYITDEKMHIARDYLEKNTRQACGIKPEQVEVTDTALLALIENYCREAGVRNLQKQIEKIYRKIALQLVRQGVSNEPDHESVSASVTEESGNGDNTTTKDEILKDPAVEDASVTNNVTNPASEEANEENLTSEAAKEDSTSKGNKGTDGAADKAIEKVVVDSSNLGDFVGKPVFQAERIYEHTPVGVVMGLAWTAMGGSTLYIETKKVEEREGKGALVLTGQLGDVMKESAQIAHTVGRAVLLEKEPDNHFFANSKVHLHVPAGSTPKDGPSAGCTMITSMLSLAMGKPVKKDLAMTGEVTLTGRILPIGGVKEKTIAARRSAIKTLIFPAANKRDFDELASNVKEGLEVHFVDTYSEIYDLAFQSDAGTETS |
| Enzyme Length | 964 |
| Uniprot Accession Number | P93648 |
| Absorption | |
| Active Site | ACT_SITE 863; /evidence=ECO:0000255|HAMAP-Rule:MF_03120; ACT_SITE 906; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; Evidence={ECO:0000255|HAMAP-Rule:MF_03120}; |
| DNA Binding | |
| EC Number | 3.4.21.53 |
| Enzyme Function | FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|Ref.2}. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 40-45 degrees Celsius. {ECO:0000269|Ref.2}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 8.5-9.0. {ECO:0000269|Ref.2}; |
| Pathway | |
| nucleotide Binding | NP_BIND 455..462; /note=ATP; /evidence=ECO:0000255|HAMAP-Rule:MF_03120 |
| Features | Active site (2); Chain (1); Compositional bias (3); Domain (2); Nucleotide binding (1); Region (1) |
| Keywords | ATP-binding;DNA-binding;Hydrolase;Mitochondrion;Nucleotide-binding;Protease;Reference proteome;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|Ref.2}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 105,659 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |