| IED ID | IndEnz0002007320 |
| Enzyme Type ID | protease007320 |
| Protein Name |
Leishmanolysin-like peptidase EC 3.4.24.- Invadolysin |
| Gene Name | Invadolysin l(3)IX-14 CG3953 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MAKTPPLRPHGNMAKFLAALGICSWLLVSATAHNCQHQHPKAHEVVHGVRIQLADSEDDSAGDPARHSVRRRSVAAEQPLRILLVYDESVYRLEEEKFNLINDTVLPEAVQFWEQALMVRETKGVIRLNRKCDSTQVYVKNGHTHCIDHCKATTMCGEVQVPDAHLDVCRVCNATGQNCRIDSNTQPGEGIENADFVFYVSARQTQRCFKGLTVAYAAHCQQEAALDRPIAGHANLCPESISTKPQELQTLISTVKHEILHALGFSVSLYAFFRDDDGKPRTPRKLDTGKPYLNEKLQIHQWSNETIRKVVRENWSVRGGHVNKVVDMMVTPRVIAEVRAHFNCNKLEGAELEDQGGEGTALTHWEKRILENEAMTGTHTQSPVFSRITLALMEDSGWYRANYSMATPLTWGKGLGCAFAMRSCKDWIQYNHARGRSIHPFCSKVKQDPLQTECTDDRNSVALCNLIRHEFELPKGYQNFDSLNHVKDGEEGFYGGSVSLADHCPYIQEFTWRSKNVIVRGSHCRFTENNPRPEKNFALESYGEGAKCFDHSESMWEERSCHQTREWQHWGSGCYKYDCFDGRLHILVGNYSYKCSFPGQKLSIRIAANGWLHKGAIMCPPCHELCGAQFAAQGKQCRPGEEPDPLNKYPRDNLACGAGSEKSRSVAIITAVLLLFGLRWGFS |
| Enzyme Length | 683 |
| Uniprot Accession Number | Q9VH19 |
| Absorption | |
| Active Site | ACT_SITE 258; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Essential for the coordination of mitotic progression, and also plays a role in cell migration. {ECO:0000269|PubMed:15557119}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3) |
| Keywords | Cell cycle;Cell division;Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Mitosis;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15557119}. Note=Found in ring-like structures resembling invadopodia. In migrating cells it relocalizes from internal structures to the leading edge of cells. {ECO:0000269|PubMed:15557119}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16624914; 19706689; 19781664; 20220848; 20371351; 20440302; 21074052; 23071443; 23943867; 2498166; 25687947; 25779050; 26182199; 27172210; 29440697; 29670218; 31722958; 34568906; 7672606; |
| Motif | |
| Gene Encoded By | |
| Mass | 76,978 |
| Kinetics | |
| Metal Binding | METAL 257; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 261; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 364; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |