| IED ID | IndEnz0002007413 |
| Enzyme Type ID | protease007413 |
| Protein Name |
Pro-apoptotic serine protease NMA111 EC 3.4.21.- |
| Gene Name | NMA111 KLLA0F24090g |
| Organism | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Kluyveromyces Kluyveromyces lactis (Yeast) (Candida sphaerica) Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) |
| Enzyme Sequence | MTVELKRNLLESSVEDIDLESKKQRVDNDVDQNTSSVDEDIDYEEDYDEVNDVPIDSGNSLFNNNAKWQETISKVVKSVVSIHFSQVAPFDSEAALVSEATGFIVDAKLGIILTNRHVVGPGPFIGYAIFDNHEECDVIPIYRDPVHDFGFLKFDPSKLKYIEVTALELKPSLAKVGSEIRVVGNDAGEKLSILSGFISRLDRNAPDYGELTYNDFNTEYIQAAAAASGGSSGSPVITVEGYAVALQAGGSSEASTDFFLPLDRVVRALQCVQTDKPITRGTIQTQWVLKPFDECRRLGLSEDREKEARKRFPGKTGLLVAEAILREGPAYNKVQEGDTLISINGTPICSFIQVDNILDSSVGDEIIIVVQRGSKDISFRCTVGDLHIITPSRYVEVCGANFHELSYQMARCYALPVKGVFVASATGSFDLDPKEKTGWVIDFVDNKETPTLDDFIEVMKTIPDEKRVIVKFHNLTDVQTQRITSVYIDRHWCSEFRIYTRNDKTGIWDYEKITEKLPPLPIKPQKAKILDLPINDNKKLAKMSHSLCVVHSVIAITMDSMEPEPTNGCGLVLDAEKGYVIVSRSFVPHDCLNTFVSFAESILVPAKVVFLHPTQNYAIVQYDPSLVDAPVCTPVLANERLERGDETNFIGYMYSNTLISSKTKVNGISSLSVPNDIIPRYRATNLEVISIDSNISTKCKSGILAADDGTVRAIWLSCMGNKEKLYLMGLDVVDIKEVVDILRAGKNPKVSIVDAGFDSISLLQARIRGVPEEWIKMMEEESENRLQFISVTRNSYTTIKERLEPGDIILSVNGKLVKRMRDIGGVVGTDDDTDIESELLFKVVRDAKVIDLKIKTVQIEETTRIVVFAGCVLQAPHHAVRQVKTSIPSEVYAVSRGTSSLALQYGIEVTNFITHVNDQSTPDLDTFLKVVKEIPDNTYCKLRLMTFDDVPFAISLKTNYHYFPTVELRKNPKTGSWIENDISET |
| Enzyme Length | 985 |
| Uniprot Accession Number | Q6CIT6 |
| Absorption | |
| Active Site | ACT_SITE 117; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 148; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 231; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (2); Region (1) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 109,647 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |