| IED ID | IndEnz0002007457 |
| Enzyme Type ID | protease007457 |
| Protein Name |
Packaging protein 3 L1-52/55 kDa protein Packaging protein 52K |
| Gene Name | L1 |
| Organism | Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) |
| Taxonomic Lineage | Viruses Varidnaviria Bamfordvirae Preplasmiviricota Tectiliviricetes Rowavirales Adenoviridae Mastadenovirus Human mastadenovirus C Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) |
| Enzyme Sequence | MHPVLRQMRPPPQQRQEQEQRQTCRAPSPSPTASGGATSAADAAADGDYEPPRRRARHYLDLEEGEGLARLGAPSPERHPRVQLKRDTREAYVPRQNLFRDREGEEPEEMRDRKFHAGRELRHGLNRERLLREEDFEPDARTGISPARAHVAAADLVTAYEQTVNQEINFQKSFNNHVRTLVAREEVAIGLMHLWDFVSALEQNPNSKPLMAQLFLIVQHSRDNEAFRDALLNIVEPEGRWLLDLINILQSIVVQERSLSLADKVAAINYSMLSLGKFYARKIYHTPYVPIDKEVKIEGFYMRMALKVLTLSDDLGVYRNERIHKAVSVSRRRELSDRELMHSLQRALAGTGSGDREAESYFDAGADLRWAPSRRALEAAGAGPGLAVAPARAGNVGGVEEYDEDDEYEPEDGEY |
| Enzyme Length | 415 |
| Uniprot Accession Number | P03262 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolytic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation. {ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:15681437, ECO:0000269|PubMed:16439552, ECO:0000269|PubMed:18337584, ECO:0000269|PubMed:24227847}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Modified residue (2); Region (4); Site (1) |
| Keywords | Direct protein sequencing;Host nucleus;Late protein;Phosphoprotein;Reference proteome;Viral genome packaging;Viral release from host cell |
| Interact With | |
| Induction | INDUCTION: Expressed in the early phase and late phase of the viral replicative cycle. {ECO:0000255|HAMAP-Rule:MF_04058}. |
| Subcellular Location | SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:1527852}. Note=Nuclear protein present in empty capsids and assembly intermediates. {ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:1527852}. |
| Modified Residue | MOD_RES 75; /note="Phosphoserine; by host"; /evidence="ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:22939182"; MOD_RES 360; /note="Phosphoserine; by host"; /evidence="ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:22939182" |
| Post Translational Modification | PTM: Cleaved at different sites by the viral protease during virion maturation. {ECO:0000255|HAMAP-Rule:MF_04058, ECO:0000269|PubMed:24227847}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 46,996 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |