| IED ID | IndEnz0002007479 |
| Enzyme Type ID | protease007479 |
| Protein Name |
Presenilin homolog DmPS EC 3.4.23.- dPS |
| Gene Name | Psn PS CG18803 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MAAVNLQASCSSGLASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGGGGGSGGPPTNEMEEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFYNSTDVYLLYTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTYLYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEWTAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATASSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRGNAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGDFIFYSVLVGKASSYGDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSAVVKPFMEDLSAKQVFI |
| Enzyme Length | 541 |
| Uniprot Accession Number | O02194 |
| Absorption | |
| Active Site | ACT_SITE 279; /evidence=ECO:0000250; ACT_SITE 461; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes. {ECO:0000269|PubMed:10206646, ECO:0000269|PubMed:10206647, ECO:0000269|PubMed:12660785}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (2); Chain (1); Compositional bias (3); Glycosylation (1); Intramembrane (1); Motif (1); Region (5); Sequence conflict (1); Topological domain (10); Transmembrane (8) |
| Keywords | Alternative splicing;Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Notch signaling pathway;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Cleaved. The cleavage, which probably takes place between the 6th and the 7th transmembrane regions, may be required for activation of the gamma-secretase activity. {ECO:0000269|PubMed:10662508}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10077672; 10206639; 10221902; 10399926; 10475855; 10481190; 10491396; 10523497; 10581285; 10669758; 10731134; 10783247; 10806097; 10903180; 10908582; 10924470; 10984440; 11030342; 11071766; 11090127; 11134525; 11267869; 11336782; 11390359; 11536431; 11544033; 11557046; 11739946; 11781576; 11782315; 11782316; 11799064; 11832221; 11909545; 11978763; 11983148; 12015301; 12110170; 12350339; 12351791; 12388554; 12459922; 12610523; 12642500; 12648493; 12771124; 12783893; 12944419; 14966281; 14973298; 15013662; 15102905; 15105831; 15131112; 15220354; 15611340; 15630418; 15644323; 15834138; 16103123; 16141223; 16307735; 16331645; 16341071; 16415372; 16435300; 16461271; 16487968; 16713961; 17084358; 17329245; 17336908; 17428965; 17562530; 17704509; 17937502; 17947293; 18436784; 18575606; 18604272; 18694898; 18831969; 19000840; 19049874; 19191327; 19234471; 19241393; 19295516; 19363474; 19519249; 19701455; 19730737; 19855819; 19967412; 20220848; 20371351; 20421416; 20493818; 20631179; 21074052; 21098717; 21148181; 21179466; 21315258; 21524270; 21636775; 21822800; 21912928; 22000799; 22120070; 22162134; 22190636; 22288402; 22814602; 23071443; 23152840; 23238734; 23318643; 23575664; 23599892; 23609534; 23667524; 23671640; 23710041; 24145027; 24284207; 24678921; 24704358; 24780858; 24815210; 24832605; 25242144; 25299777; 25569355; 25670792; 25697708; 25704823; 25740935; 25913403; 26060055; 26291159; 26345855; 26551273; 27816064; 27899511; 27904993; 27932950; 28152299; 28257663; 28495961; 28736165; 28894399; 28923062; 28960177; 29343637; 29394281; 29478851; 29773559; 29790963; 29888266; 30030826; 30176986; 30635270; 31513679; 31585867; 31585881; 31646538; 31672849; 31822470; 31943162; 32019113; 32060870; 32259198; 32357532; 32610577; 32630239; 32829687; 32901612; 33527895; 33529757; 33800390; 34572582; 9309174; 9409831; 9851920; |
| Motif | MOTIF 507..509; /note=PAL |
| Gene Encoded By | |
| Mass | 59,304 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |