IED Industry Enzyme Database

Detail Information for IndEnz0002007561
IED ID IndEnz0002007561
Enzyme Type ID protease007561
Protein Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
EC 3.1.3.16
EC 3.1.3.48
EC 3.1.3.67
Mutated in multiple advanced cancers 1
Phosphatase and tensin homolog
Gene Name PTEN MMAC1 TEP1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV
Enzyme Length 403
Uniprot Accession Number P60484
Absorption
Active Site ACT_SITE 124; /note=Phosphocysteine intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU00590
Activity Regulation ACTIVITY REGULATION: Enzymatic activity is enhanced in the presence of phosphatidylserine. {ECO:0000269|PubMed:16824732}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:25017, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57836, ChEBI:CHEBI:58456; EC=3.1.3.67; Evidence={ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:9593664, ECO:0000269|PubMed:9811831}; CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:9256433}; CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:9256433}; CATALYTIC ACTIVITY: Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000269|PubMed:9187108, ECO:0000269|PubMed:9256433}; CATALYTIC ACTIVITY: Reaction=1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:43552, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83416, ChEBI:CHEBI:83419; Evidence={ECO:0000269|PubMed:16824732};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43553; Evidence={ECO:0000305|PubMed:16824732}; CATALYTIC ACTIVITY: Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate; Xref=Rhea:RHEA:43560, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:83420, ChEBI:CHEBI:83423; Evidence={ECO:0000269|PubMed:16824732};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:43561; Evidence={ECO:0000305|PubMed:16824732};
DNA Binding
EC Number 3.1.3.16; 3.1.3.48; 3.1.3.67
Enzyme Function FUNCTION: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226, PubMed:16824732). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with MAGI2 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement. {ECO:0000269|PubMed:16824732, ECO:0000269|PubMed:26504226}.; FUNCTION: [Isoform alpha]: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Alternative sequence (4); Beta strand (25); Chain (1); Compositional bias (2); Cross-link (2); Domain (2); Helix (10); Initiator methionine (1); Modified residue (10); Mutagenesis (24); Natural variant (81); Region (3); Turn (2)
Keywords 3D-structure;Acetylation;Alternative initiation;Alternative splicing;Apoptosis;Autism spectrum disorder;Cytoplasm;Disease variant;Hydrolase;Isopeptide bond;Lipid metabolism;Lipid-binding;Neurogenesis;Nucleus;Phosphoprotein;Protein phosphatase;Reference proteome;Secreted;Tumor suppressor;Ubl conjugation
Interact With P35226; P30260; Q9P0U4; Q16643; P42685; O60307; Q9Y6Q9; P46934; P09619; Q9NRD5; P62136; Q06830; Itself; O14745; Q15599; O43791; Q62696; O88382; Q9JK71; Q9R1L5; Q60592; Q9JHL1; Q19T08; Q5T2D3; Itself; Q93009
Induction INDUCTION: Down-regulated by TGFB1. {ECO:0000269|PubMed:9187108}.
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:9187108}. Nucleus {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000269|PubMed:18716620}. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). {ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.; SUBCELLULAR LOCATION: [Isoform alpha]: Secreted {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.
Modified Residue MOD_RES 2; /note="N-acetylthreonine"; /evidence="ECO:0007744|PubMed:22814378"; MOD_RES 294; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:O08586"; MOD_RES 336; /note="Phosphotyrosine; by FRK"; /evidence="ECO:0000269|PubMed:19345329"; MOD_RES 366; /note="Phosphothreonine; by GSK3-beta and PLK3"; /evidence="ECO:0000269|PubMed:12297295, ECO:0000269|PubMed:20940307, ECO:0007744|PubMed:24275569"; MOD_RES 370; /note="Phosphoserine; by CK2 and PLK3"; /evidence="ECO:0000269|PubMed:11035045, ECO:0000269|PubMed:12297295, ECO:0000269|PubMed:20940307"; MOD_RES 380; /note="Phosphoserine; by ROCK1 and CK2"; /evidence="ECO:0000269|PubMed:11035045"; MOD_RES 382; /note="Phosphothreonine; by ROCK1 and CK2"; /evidence="ECO:0000269|PubMed:11035045"; MOD_RES 383; /note="Phosphothreonine; by ROCK1 and CK2"; /evidence="ECO:0000269|PubMed:11035045"; MOD_RES 385; /note="Phosphoserine; by CK2"; /evidence="ECO:0000269|PubMed:11035045, ECO:0000269|PubMed:12297295"; MOD_RES 401; /note="Phosphothreonine"; /evidence="ECO:0000269|PubMed:10646847"
Post Translational Modification PTM: Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11. Phosphorylation results in an inhibited activity towards PIP3. Phosphorylation can both inhibit or promote PDZ-binding. Phosphorylation at Tyr-336 by FRK/PTK5 protects this protein from ubiquitin-mediated degradation probably by inhibiting its binding to NEDD4. Phosphorylation by ROCK1 is essential for its stability and activity. Phosphorylation by PLK3 promotes its stability and prevents its degradation by the proteasome. {ECO:0000269|PubMed:10646847, ECO:0000269|PubMed:11035045, ECO:0000269|PubMed:11707428, ECO:0000269|PubMed:12297295, ECO:0000269|PubMed:15951562, ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19345329, ECO:0000269|PubMed:20940307}.; PTM: Monoubiquitinated; monoubiquitination is increased in presence of retinoic acid. Deubiquitinated by USP7; leading to its nuclear exclusion. Monoubiquitination of one of either Lys-13 and Lys-289 amino acid is sufficient to modulate PTEN compartmentalization. Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.
Signal Peptide
Structure 3D NMR spectroscopy (1); X-ray crystallography (8)
Cross Reference PDB 1D5R; 2KYL; 4O1V; 5BUG; 5BZX; 5BZZ; 7JUK; 7JUL; 7JVX;
Mapped Pubmed ID 10619020; 10866658; 11270682; 11303600; 11431330; 11476065; 11504770; 11729185; 11784722; 11799112; 11836379; 11849740; 11854177; 11870516; 11875759; 11896207; 11906179; 11908870; 11916965; 11923872; 11932928; 11948419; 11986403; 12055674; 12067477; 12077256; 12084351; 12115563; 12119278; 12133897; 12168088; 12176037; 12177006; 12190124; 12203362; 12203792; 12209607; 12235113; 12367630; 12379854; 12414663; 12415190; 12429629; 12452054; 12459646; 12495846; 12508347; 12509854; 12517803; 12535639; 12543774; 12569555; 12569572; 12569575; 12620973; 12632503; 12684422; 12687015; 12712134; 12717346; 12743124; 12743604; 12767263; 12788938; 12804776; 12808147; 12833416; 12839924; 12844284; 12857747; 12869565; 12917336; 12918097; 12960424; 14516315; 14519639; 14532122; 14534684; 14557489; 14559824; 14561749; 14566704; 14574156; 14623110; 14623898; 14642363; 14674989; 14699494; 14711368; 14724591; 14737113; 14976311; 14981940; 15009714; 15043466; 15046604; 15046605; 15053880; 15069540; 15126336; 15129904; 15172121; 15196854; 15205473; 15209376; 15231710; 15240129; 15273733; 15287024; 15382065; 15453811; 15457582; 15468057; 15476185; 15492994; 15500293; 15516982; 15517593; 15523694; 15532706; 15537704; 15551732; 15564381; 15569824; 15584861; 15589575; 15623531; 15633233; 15668893; 15674339; 15701646; 15707982; 15710331; 15725467; 15725474; 15764699; 15766664; 15784509; 15793569; 15802268; 15803130; 15824172; 15843377; 15848175; 15891996; 15897909; 15900596; 15916963; 15948123; 15968641; 15986432; 15988030; 15994292; 16012720; 16020969; 16052674; 16055704; 16088943; 16096376; 16107342; 16124450; 16169070; 16179636; 16194892; 16219695; 16220831; 16274701; 16325763; 16331670; 16331889; 16371363; 16371366; 16385451; 16418168; 16421604; 16424003; 16425372; 16432235; 16436456; 16456542; 16457151; 16487009; 16496415; 16506206; 16525657; 16537447; 1654322; 16571650; 16574322; 16598737; 16621980; 16637073; 16652388; 16676006; 16676097; 16697957; 16697958; 16702386; 16704528; 16707597; 16739377; 16773562; 16793127; 16807353; 16810057; 16818626; 16821090; 16842970; 16849370; 16872708; 16883792; 16912159; 16916644; 16938570; 16949921; 16951148; 16963781; 16964248; 16972255; 16984224; 17000554; 17006756; 17013611; 17033968; 17043057; 17060456; 17062663; 17067457; 17097286; 17101085; 17108713; 17126809; 17158952; 17178862; 17218261; 17218262; 17219201; 17235455; 17236582; 17255257; 17274640; 17277022; 17300726; 17328268; 17334236; 17341483; 17345711; 17347137; 17348444; 17357516; 17369847; 17372210; 17390041; 17392703; 17393112; 17405772; 17420249; 17427195; 17438373; 17441421; 17444818; 17452061; 17452630; 17471559; 17479230; 17483060; 17490733; 17504383; 17504928; 17520061; 17526801; 17562371; 17563403; 17565999; 17575221; 17581634; 17593340; 17606718; 17611573; 17616684; 17636424; 17638861; 17638924; 17646270; 17657213; 17657248; 17669465; 17681183; 17681738; 17684018; 17684142; 17699782; 17700571; 17701929; 17706140; 17711623; 17713092; 17727244; 17729405; 17761400; 17786367; 17826033; 17826953; 17827710; 17845801; 17847000; 17873065; 17873119; 17873882; 17880912; 17886097; 17895757; 17911267; 17912443; 17919877; 17924977; 17927875; 17927889; 17928923; 17936563; 17939398; 17940504; 17949781; 17954274; 17958724; 17959258; 17974977; 17982625; 17991315; 18006852; 18059158; 18064632; 18065496; 18066063; 18072631; 18091387; 18174230; 18178612; 18199536; 18199538; 18216329; 18220422; 18226337; 18226854; 18231751; 18239055; 18240926; 18240930; 18260377; 18271247; 18307411; 18316341; 18321849; 18324520; 18327259; 18332125; 18332865; 18335551; 18335752; 18339852; 18339899; 18363844; 18383208; 18391023; 18424911; 18425369; 18431376; 18456716; 18460397; 18474617; 18482992; 18497947; 18500270; 18510548; 18519768; 18544045; 18559622; 18563337; 18579579; 18586681; 18594467; 18599181; 18609703; 18616639; 18620995; 18632658; 18632660; 18652763; 18660489; 18662848; 18669866; 18676680; 18676830; 18678645; 18700047; 18702307; 18714395; 18720079; 18723495; 18726116; 18728972; 18755892; 18757403; 18757404; 18759867; 18765664; 18769113; 18781191; 18781614; 18787170; 18787206; 18794875; 18794882; 18815879; 18826385; 18830414; 18831514; 18844062; 18846217; 18854827; 18928601; 18937284; 18948956; 18950007; 18953692; 19007975; 19010541; 19016009; 19036165; 19055754; 19064572; 19072831; 19075230; 19079342; 19079986; 19103758; 19107233; 19116269; 19125794; 19147772; 19158375; 19164214; 19168705; 19170196; 19173293; 19185849; 19189642; 19190120; 19206008; 19206163; 19208634; 19211894; 19212625; 19212633; 19221500; 19224164; 19225041; 19234438; 19237173; 19242756; 19261747; 19261849; 19265751; 19276385; 19276401; 19293259; 19318457; 19336370; 19339266; 19339269; 19340001; 19350382; 19351817; 19369943; 19373662; 19379695; 19398573; 19402094; 19407556; 19407851; 19417140; 19420344; 19428048; 19435893; 19437103; 19440552; 19443396; 19443706; 19457929; 19458356; 19463221; 19470463; 19470765; 19471547; 19478684; 19479935; 19482022; 19483472; 19486858; 19487573; 19492080; 19502790; 19503063; 19506903; 19508975; 19522184; 19540498; 19560785; 19563023; 19567590; 19574087; 19608668; 19615424; 19625176; 19629644; 19635806; 19638581; 19641183; 19641606; 19648120; 19657395; 19661141; 19665071; 19672202; 19673018; 19679016; 19681904; 19692168; 19696618; 19724853; 19729658; 19730150; 19730774; 19733443; 19740742; 19763916; 19764563; 19764572; 19781346; 19781347; 19784964; 19787268; 19789190; 19795445; 19798057; 19808686; 19829307; 19843859; 19846776; 19853286; 19861688; 19864456; 19881543; 19884556; 19884659; 19903340; 19911253; 19913121; 19915616; 19922411; 19930417; 19940030; 19953097; 19962668; 20004652; 20018398; 20029030; 20032390; 20056007; 20067111; 20079181; 20079187; 20079711; 20080666; 20087603; 20102402; 20103602; 20104229; 20113523; 20123964; 20154081; 20169661; 20173664; 20175786; 20177066; 20186503; 20198299; 20198337; 20208477; 20211060; 20211065; 20212113; 20223231; 20226014; 20231295; 20237279; 20237868; 20300775; 20305378; 20309867; 20338046; 20349131; 20358487; 20371743; 20372838; 20381115; 20388916; 20389136; 20393024; 20395445; 20400965; 20407443; 20407866; 20419107; 20430845; 20444542; 20447721; 20453000; 20465090; 20467490; 20472848; 20505137; 20506484; 20514448; 20515662; 20523723; 20529558; 20533527; 20546613; 20565722; 20576813; 20580873; 20590547; 20596030; 20600018; 20608352; 20610402; 20622004; 20622047; 20628086; 20628624; 20631067; 20634891; 20637195; 20646419; 20664988; 20673489; 20677014; 20705603; 20711233; 20711500; 20712882; 20718038; 20718712; 20736378; 20736773; 20797623; 20813662; 20813970; 20818428; 20822910; 20845481; 20854947; 20862607; 20864106; 20878123; 20881644; 20889565; 20926450; 20929508; 20954279; 20955384; 20956547; 20959484; 20975834; 21029699; 21040738; 21042725; 21042775; 21042784; 21045203; 21076047; 21084621; 21093899; 21103049; 21104017; 21110069; 21114918; 21116717; 21118966; 21129241; 21138334; 21146147; 21148296; 21151099; 21155011; 21162897; 21170675; 21177507; 21178509; 21181309; 21187093; 21194879; 21203412; 21225506; 21228352; 21241890; 21252315; 21289308; 21290340; 21291452; 21297666; 21303970; 21313761; 21317224; 21333374; 21343951; 21354147; 21358673; 21371429; 21404710; 21407808; 21412012; 21417916; 21421471; 21423810; 21430697; 21454687; 21456062; 21465511; 21467840; 21473780; 21486223; 21489309; 21490305; 21518490; 21521253; 21527520; 21529704; 21531001; 21532586; 21532617; 21536651; 21556061; 21559530; 21565140; 21575512; 21575859; 21602918; 21613227; 21620777; 21623071; 21627959; 21633361; 21637289; 21642958; 21646525; 21654839; 21664656; 21685691; 21688200; 21696297; 21698421; 21719208; 21725359; 21771908; 21804599; 21819957; 21820606; 21823007; 21824802; 21828076; 21840483; 21846942; 21860425; 21873427; 21874010; 21881486; 21890624; 21901275; 21921783; 21943825; 21948699; 21952626; 21952639; 21956414; 21960672; 21984976; 21989717; 21990315; 22000013; 22019339; 22019626; 22020193; 22021428; 22033727; 22036936; 22037217; 22045666; 22052239; 22072715; 22074495; 22075159; 22076652; 22080063; 22086610; 22095074; 22095222; 22103913; 22105477; 22110200; 22127531; 22149168; 22162762; 22166214; 22171747; 22172323; 22184110; 22185283; 22205501; 22209682; 22209699; 22213145; 22240798; 22248055; 22252256; 22262409; 22266152; 22267008; 22281088; 22285706; 22290228; 22299584; 22301279; 22301622; 22301702; 22320969; 22320991; 22327138; 22333553; 22336203; 22336889; 22341591; 22347425; 22350410; 22374676; 22375056; 22389271; 22394497; 22403079; 22413021; 22413754; 22416141; 22427670; 22429330; 22434720; 22465665; 22473468; 22477202; 22479427; 22486434; 22491738; 22493444; 22498935; 22505997; 22520842; 22521126; 22552802; 22556379; 22563025; 22586484; 22595938; 22613768; 22614013; 22628410; 22635024; 22639407; 22664040; 22674438; 22678116; 22679820; 22682934; 22684219; 22685558; 22689060; 22690848; 22700876; 22700976; 22705054; 22713753; 22727345; 22744290; 22753230; 22759273; 22759359; 22766795; 22770403; 22781804; 22810004; 22815832; 22820083; 22872167; 22879939; 22891331; 22892847; 22902055; 22907762; 22912864; 22937575; 22938441; 22939387; 22944341; 22949843; 22955108; 22956424; 22956625; 22958183; 22970944; 22982652; 22990545; 22995297; 22999923; 23013295; 23013792; 23015639; 23018874; 23030486; 23039341; 23060044; 23064324; 23066114; 23068025; 23068099; 23082988; 23085752; 23086302; 23104175; 23110505; 23117110; 23117887; 23119114; 23124040; 23125220; 23129115; 23133538; 23135913; 23138198; 23139750; 23144700; 23150879; 23151319; 23158210; 23161105; 23167185; 23171135; 23174819; 23178856; 23183427; 23186335; 23189187; 23206599; 23219661; 23219716; 23222491; 23223894; 23242174; 23242608; 23249714; 23260327; 23274758; 23275086; 23291982; 23310986; 23314408; 23319441; 23321166; 23345234; 23348902; 23349303; 23361940; 23361946; 23375407; 23382303; 23391506; 23397142; 23399955; 23402578; 23416162; 23419514; 23419777; 23421960; 23426367; 23428429; 23434594; 23435381; 23464451; 23464465; 23465274; 23475934; 23477121; 23514585; 23533567; 23545904; 23546450; 23546539; 23574264; 23574721; 23589096; 23589550; 23591626; 23592446; 23595342; 23599148; 23603434; 23604118; 23612073; 23613387; 23613406; 23613428; 23617834; 23623571; 23623999; 23633456; 23633918; 23636253; 23639623; 23653096; 23660947; 23670029; 23684551; 23686804; 23695019; 23695273; 23715078; 23715080; 23715723; 23728071; 23732914; 23754155; 23764071; 23765252; 23783762; 23786676; 23787493; 23788636; 23796801; 23796964; 23802662; 23805267; 23811847; 23813545; 23817021; 23819399; 23832602; 23840064; 23848554; 23851329; 23856247; 23867821; 23883586; 23888040; 23902739; 23907540; 23908595; 23917528; 23934601; 23936141; 23938948; 23940795; 23963458; 23980519; 23983239; 23989949; 23992303; 23993026; 23995781; 23996432; 24004025; 24012691; 24012959; 24026406; 24030769; 24037976; 24038283; 24047694; 24053672; 24056966; 24062018; 24063548; 24076665; 24081673; 24084898; 24091144; 24098536; 24098737; 24099768; 24099866; 24100613; 24102544; 24113181; 24123798; 24132918; 24133589; 24140063; 24141770; 24143235; 24149576; 24154570; 24155249; 24155657; 24156022; 24162827; 24166518; 24167614; 24168180; 24168499; 24170201; 24187456; 24188406; 24218517; 24221338; 24270891; 24284056; 24284390; 24286315; 24292675; 24292679; 24295494; 24323028; 24344134; 24346286; 24348097; 24349488; 24356815; 24366426; 24367090; 24380696; 24391010; 24395742; 24409057; 24412244; 24413994; 24417635; 24419422; 24422746; 24434152; 24462867; 24468202; 24468585; 24482365; 24483290; 24486402; 24491799; 24494199; 24498881; 24510842; 24515759; 24531711; 24532253; 24535608; 24552815; 24556061; 24564252; 24569712; 24571667; 24573625; 24577094; 24580998; 24582960; 24587660; 24588644; 24595598; 24596386; 24603487; 24603539; 24604064; 24624456; 24625059; 24632578; 24647137; 24647592; 24656772; 24659669; 24666267; 24685694; 24704020; 24704156; 24706748; 24712384; 24718924; 24727891; 24740298; 24743220; 24747746; 24762546; 24766807; 24767865; 24778394; 24788349; 24809452; 24811168; 24830350; 24831963; 24838891; 24840811; 24842611; 24844349; 24854395; 24858043; 24866151; 24867318; 24892215; 24898805; 24901890; 24905916; 24911372; 24912422; 24929707; 24935469; 24958106; 24961634; 24970800; 24976139; 24979808; 24983247; 24985344; 24993522; 24994750; 25003235; 25003471; 25022554; 25033601; 25047839; 25051360; 25056500; 25058005; 25069680; 25076292; 25088198; 25101889; 25110169; 25111376; 25116353; 25120782; 25124605; 25125078; 25127200; 25128467; 25139413; 25146530; 25148875; 25149476; 25149900; 25152374; 25152517; 25174622; 25184346; 25195947; 25216078; 25233425; 25239565; 25241761; 25263454; 25267489; 25270723; 25272061; 25277183; 25288137; 25293520; 25310480; 25314059; 25330770; 25336918; 25343485; 25347742; 25348345; 25361012; 25365510; 25372501; 25378175; 25388655; 25409150; 25414139; 25429968; 25446078; 25446882; 25448478; 25454348; 25472613; 25527629; 25542038; 25543086; 25547115; 25549896; 25550771; 25554686; 25556430; 25562748; 25571952; 25576921; 25595786; 25596747; 25603978; 25607987; 25608477; 25608759; 25609695; 25623744; 25625883; 25631336; 25633810; 25634356; 25637514; 25638032; 25638724; 25640309; 25641678; 25645159; 25646931; 25647146; 25647261; 25659997; 25661333; 25661377; 25662849; 25669429; 25679447; 25682871; 25695913; 25701194; 25724568; 25725586; 25728608; 25735379; 25738254; 25750291; 25756512; 25771877; 25773992; 25777795; 25801032; 25803229; 25810340; 25818291; 25823029; 25829425; 25829446; 25832654; 25833835; 25845681; 25850957; 25851628; 25861022; 25861627; 25867342; 25869624; 25870146; 25871383; 25873394; 25875300; 25881543; 25883222; 25884169; 25892179; 25896712; 25897494; 25909167; 25913476; 25925379; 25925849; 25937288; 25939393; 25954860; 25963289; 25963606; 25968876; 25973003; 25981902; 25986931; 25989274; 25998046; 26024525; 26026735; 26028029; 26030748; 26045339; 26045752; 26055143; 26056945; 26061565; 26063204; 26078940; 26082156; 26087719; 26098881; 26106610; 26107197; 26107225; 26112748; 26114084; 26122142; 26124336; 26125866; 26158445; 26166433; 26166648; 26166715; 26178158; 26183061; 26189250; 26191286; 26193216; 26212011; 26220040; 26222500; 26223264; 26224641; 26230405; 26232326; 26247526; 26248734; 26251180; 26252022; 26259512; 26264443; 26265437; 26269411; 26280536; 26284486; 26294099; 26296312; 26299428; 26299948; 26306906; 26311740; 26316702; 26317552; 26318586; 26323677; 26328886; 26333042; 26357655; 26376893; 26379078; 26383228; 26385178; 26397386; 26399523; 26403191; 26415504; 26417029; 26418532; 26424596; 26432332; 26443266; 26479035; 26482612; 26492563; 26496641; 26499912; 26500061; 26511107; 26514456; 26518664; 26522776; 26526582; 26527737; 26530486; 26531778; 26541596; 26545495; 26548909; 26549452; 26554830; 26561776; 26562020; 26563373; 26568302; 26586294; 26612463; 26615022; 26617813; 26626801; 26632666; 26636539; 26645196; 26649861; 26651881; 26657567; 26660904; 26666820; 26672755; 26686085; 26686089; 26687648; 26689514; 26692175; 26695147; 26701805; 26715274; 26718740; 26722456; 26722535; 26725250; 26743285; 26750720; 26754093; 26758558; 26774334; 26779632; 26782378; 26787105; 26787927; 26791485; 26794644; 26800850; 26802879; 26813356; 26822433; 26823866; 26843422; 26846484; 26846737; 26853466; 26854490; 26861561; 26861608; 26864640; 26864725; 26869029; 26880795; 26893028; 26894937; 26905328; 26931395; 26967567; 26975392; 26975628; 26986476; 27010857; 27035216; 27040383; 27044817; 27049078; 27059323; 27068875; 27076758; 27082228; 27082730; 27097697; 27107786; 27113763; 27121319; 27133296; 27146957; 27148794; 27165243; 27173355; 27174589; 27188433; 27189342; 27220494; 27221918; 27223069; 27226612; 27229116; 27230035; 27240320; 27249819; 27259304; 27261580; 27264420; 27278879; 27285754; 27292259; 27294619; 27296289; 27323121; 27326759; 27333149; 27339596; 27357679; 27362804; 27363339; 27367846; 27381864; 27387578; 27398835; 27400681; 27405757; 27412938; 27421660; 27423040; 27426521; 27432152; 27465551; 27465552; 27466505; 27467187; 27470558; 27477328; 27481051; 27498785; 27499479; 27500376; 27502248; 27506936; 27508324; 27510094; 27517839; 27525871; 27534652; 27542208; 27548517; 27572308; 27572739; 27591748; 27611950; 27613140; 27620353; 27626703; 27634912; 27644195; 27644439; 27650731; 27661110; 27677222; 27685929; 27693448; 27694004; 27694005; 27698265; 27699665; 27712596; 27717083; 27738792; 27741411; 27744455; 27746366; 27748285; 27756877; 27759908; 27779101; 27791035; 27822469; 27823967; 27829222; 27862321; 27862460; 27863432; 27864123; 27910065; 27974211; 27974696; 27980214; 27983532; 27986563; 28008153; 28029649; 28030829; 28040201; 28042869; 28053323; 28057891; 28069380; 28075472; 28097440; 28106296; 28124240; 28129115; 28132399; 28145479; 28158451; 28164237; 28166537; 28177757; 28186998; 28192480; 28213783; 28220037; 28235656; 28242043; 28253285; 28258103; 28259931; 28263967; 28280276; 28285689; 28289760; 28306514; 28321407; 28322462; 28332494; 28337018; 28349562; 28351303; 28388883; 28400560; 28402859; 28402921; 28410191; 28411180; 28413152; 28415790; 28418888; 28423632; 28437168; 28442995; 28447761; 28459373; 28464252; 28475001; 28497778; 28498467; 28499984; 28504208; 28509866; 28513612; 28522564; 28529243; 28534966; 28539671; 28543796; 28544358; 28557373; 28559303; 28559385; 28603902; 28608528; 28614300; 28620008; 28621226; 28631420; 28639901; 28646488; 28672019; 28677221; 28683304; 28684904; 28688620; 28710314; 28713931; 28713947; 28714370; 28720772; 28723560; 28723738; 28731027; 28749339; 28750640; 28755140; 28759753; 28765915; 28766684; 28772212; 28774669; 28774816; 28783500; 28791363; 28801478; 28823542; 28844858; 28852924; 28854563; 28857248; 28858374; 28872922; 28878269; 28885360; 28886696; 28888922; 28910982; 28911096; 28919047; 28935812; 28941804; 28944868; 28967905; 28972046; 29030742; 29052531; 29056325; 29057971; 29103158; 29108454; 29110152; 29111166; 29115407; 29115464; 29117568; 29142193; 29154111; 29160937; 29170871; 29175021; 29175594; 29175997; 29185784; 29192321; 29204743; 29207012; 29209894; 29221176; 29229583; 29239139; 29246444; 29257342; 29259266; 29283497; 29298524; 29302046; 29303510; 29316891; 29328452; 29328455; 29329300; 29335012; 29341212; 29353884; 29361670; 29367766; 29393355; 29396668; 29408173; 29408377; 29408595; 29436592; 29449346; 29467331; 29477866; 29484437; 29487004; 29488607; 29500400; 29512701; 29512776; 29522753; 29530061; 29531214; 29550515; 29566768; 29581176; 29581186; 29593330; 29608813; 29620214; 29621096; 29653745; 29654167; 29673440; 29684080; 29706633; 29717200; 29729889; 29734016; 29740032; 29745082; 29749435; 29767245; 29770434; 29783075; 29788382; 29802838; 29803738; 29807230; 29807978; 29843123; 29844131; 29845190; 29857052; 29876362; 29880482; 29898896; 29902454; 29902839; 29916551; 29916735; 29917188; 29921876; 29934616; 29936638; 29938780; 29941984; 29946925; 29954386; 29957460; 29958993; 29964149; 29969932; 29987362; 30003758; 30015900; 30015974; 30018330; 30021354; 30060954; 30074182; 30100056; 30101374; 30111295; 30131483; 30132256; 30132571; 30134003; 30134988; 30149868; 30212483; 30217221; 30217930; 30221692; 30221716; 30227836; 30246429; 30254159; 30291535; 30302796; 30318571; 30327302; 30335891; 30337688; 30338782; 30338796; 30338800; 30338819; 30338929; 30348959; 30357833; 30358192; 30362552; 30365133; 30372795; 30373357; 30415006; 30418964; 30421325; 30430607; 30431097; 30431102; 30431133; 30455992; 30456390; 30472379; 30478503; 30482097; 30496141; 30503497; 30544451; 30548445; 30550871; 30553611; 30556865; 30569117; 30575901; 30576678; 30584245; 30594392; 30595797; 30598407; 30609280; 30649986; 30666836; 30673593; 30678449; 30690477; 30700111; 30722993; 30727918; 30738963; 30765787; 30777076; 30781615; 30784286; 30792481; 30811870; 30814496; 30823937; 30827889; 30834525; 30834688; 30840927; 30841423; 30849539; 30868052; 30886105; 30896881; 30912184; 30914801; 30921702; 30925916; 30928405; 30930234; 30938910; 30940319; 30943822; 30950039; 30964887; 30975145; 30977354; 30981721; 30983514; 30993208; 30999388; 31006103; 31011573; 31018950; 31025173; 31025251; 31033083; 31038023; 31043790; 31062505; 31066051; 31074114; 31074594; 31087222; 31094930; 31109254; 31110221; 31111513; 31126975; 31127935; 31128020; 31128026; 31128066; 31129769; 31144376; 31151164; 31158447; 31169889; 31185211; 31196157; 31206229; 31209806; 31212131; 31213464; 31217297; 31218569; 31221815; 31228937; 31241130; 31247032; 31257492; 31257524; 31270249; 31270271; 31307976; 31318186; 31318685; 31332950; 31337279; 31341016; 31364122; 31364744; 31379809; 31411121; 31411988; 31421682; 31424647; 31427284; 31444971; 31450893; 31451538; 31464538; 31474552; 31486504; 31486513; 31492635; 31498707; 31500630; 31501265; 31501268; 31530568; 31537838; 31539127; 31545428; 31545464; 31545465; 31548229; 31554385; 31558773; 31570373; 31571016; 31591355; 31594766; 31594918; 31599805; 31621072; 31633295; 31636093; 31636388; 31638259; 31646553; 31663655; 31677789; 31682848; 31685992; 31703360; 31711642; 31719211; 31730755; 31740976; 31744268; 31754047; 31786856; 31791268; 31799671; 31801949; 31825175; 31841199; 31858547; 31863623; 31864232; 31871240; 31894272; 31896494; 31897898; 31898539; 31899608; 31900915; 31909517; 31947601; 31954745; 31960416; 31971667; 31981466; 32014919; 32016465; 32020207; 32033487; 32052576; 32094299; 32098071; 32101017; 32129857; 32134755; 32134893; 32141547; 32145584; 32150788; 32162695; 32162707; 32162846; 32186762; 32228695; 32234455; 32234883; 32242003; 32271413; 32277687; 32279917; 32281513; 32282501; 32286703; 32287115; 32294598; 32307900; 32314732; 32319598; 32319862; 32323738; 32329837; 32334006; 32345672; 32350270; 32365051; 32380791; 32394474; 32412786; 32417759; 32422900; 32423803; 32424736; 32430488; 32442409; 32467227; 32471246; 32471980; 32479694; 32512654; 32517731; 32521902; 32528035; 32532965; 32537792; 32541092; 32552146; 32555365; 32561161; 32568377; 32579864; 32583210; 32583575; 32587106; 32601921; 32605911; 32626774; 32626930; 32627866; 32628111; 32633341; 32634262; 32661238; 32663416; 32673396; 32711584; 32719259; 32727102; 32728066; 32744308; 32745469; 32754865; 32754899; 32773006; 32775453; 32787437; 32808450; 32815529; 32823607; 32827577; 32831114; 32862368; 32862621; 32881386; 32891771; 32899927; 32901835; 32901892; 32917956; 32919989; 32931887; 32939058; 32941675; 32958674; 32959437; 32967970; 32975076; 32985648; 32991951; 32997362; 32997991; 33028948; 33040228; 33051413; 33099953; 33109573; 33135071; 33146930; 33150661; 33153033; 33155366; 33166087; 33179755; 33186519; 33215426; 33220333; 33221821; 33228208; 33229547; 33230782; 33248711; 33262514; 33287921; 33308182; 33318536; 33323972; 33332075; 33332708; 33345649; 33382810; 33402463; 33407724; 33416121; 33422488; 33423167; 33431662; 33448321; 33467964; 33495842; 33509259; 33538241; 33540467; 33576342; 33595755; 33606974; 33627383; 33664240; 33686397; 33721218; 33745222; 33760104; 33760113; 33772548; 33779753; 33783672; 33813678; 33828085; 33848262; 33874915; 33876327; 33876722; 33881725; 33895342; 33907203; 33919657; 33941772; 33947796; 33970415; 33973090; 33986306; 33993982; 34006834; 34012039; 34048549; 34091997; 34154611; 34184188; 34214875; 34232796; 34239033; 34240392; 34251961; 34273354; 34307670; 34311724; 34362334; 34371011; 34377593; 34397726; 34400892; 34416231; 34453780; 34476500; 34492006; 34493366; 34575999; 34582065; 34592789; 34625746; 34638586; 34706508; 34793697; 34831026; 34943931; 8128219; 8681945; 9326929;
Motif
Gene Encoded By
Mass 47,166
Kinetics
Metal Binding
Rhea ID RHEA:25017; RHEA:20629; RHEA:47004; RHEA:10684; RHEA:43552; RHEA:43553; RHEA:43560; RHEA:43561
Cross Reference Brenda 3.1.3.16;3.1.3.67;