| IED ID | IndEnz0002007574 |
| Enzyme Type ID | protease007574 |
| Protein Name |
Proteasome subunit alpha 20S proteasome alpha subunit Proteasome core protein PrcA |
| Gene Name | prcA SACE_2252 |
| Organism | Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Pseudonocardiales Pseudonocardiaceae Saccharopolyspora Saccharopolyspora erythraea (Streptomyces erythraeus) Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) |
| Enzyme Sequence | MTMPFYTSPEQLMRERSELARKGIARGRSVVVLKYAGGVLFVAENPSTTLHKVSEIYDRIGFAAVGRYSEFESLRVAGVRIADVRGYSYDRRDVTGRALANTYAQHLGAIFTEQIKPFEVEICVAEVGQTADNDQLYRLTYDGSIVDEPQYVVMGGQADTITTTLKDSFSDGLELAEAAGLAIRALSSGGEGTRELGVGQLEVAVLDRARPNRTFRRITGAALKALLPSQEESGSTDGEASGDAGDDKKTGDDKKS |
| Enzyme Length | 256 |
| Uniprot Accession Number | A4FBY2 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. {ECO:0000255|HAMAP-Rule:MF_00289}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. {ECO:0000255|HAMAP-Rule:MF_00289}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein degradation; proteasomal Pup-dependent pathway. {ECO:0000255|HAMAP-Rule:MF_00289}. |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Region (1) |
| Keywords | Cytoplasm;Proteasome;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00289}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 27,685 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |