| IED ID | IndEnz0002007625 |
| Enzyme Type ID | protease007625 |
| Protein Name |
Renin-2 EC 3.4.23.15 Angiotensinogenase Submandibular gland renin Cleaved into: Renin-2 heavy chain; Renin-2 light chain |
| Gene Name | Ren2 Ren-2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MDRRRMPLWALLLLWSPCTFSLPTGTTFERIPLKKMPSVREILEERGVDMTRLSAEWDVFTKRSSLTDLISPVVLTNYLNSQYYGEIGIGTPPQTFKVIFDTGSANLWVPSTKCSRLYLACGIHSLYESSDSSSYMENGDDFTIHYGSGRVKGFLSQDSVTVGGITVTQTFGEVTELPLIPFMLAQFDGVLGMGFPAQAVGGVTPVFDHILSQGVLKEKVFSVYYNRGPHLLGGEVVLGGSDPEHYQGDFHYVSLSKTDSWQITMKGVSVGSSTLLCEEGCEVVVDTGSSFISAPTSSLKLIMQALGAKEKRLHEYVVSCSQVPTLPDISFNLGGRAYTLSSTDYVLQYPNRRDKLCTVALHAMDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR |
| Enzyme Length | 401 |
| Uniprot Accession Number | P00796 |
| Absorption | |
| Active Site | ACT_SITE 101; ACT_SITE 286 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.; EC=3.4.23.15; |
| DNA Binding | |
| EC Number | 3.4.23.15 |
| Enzyme Function | FUNCTION: Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (23); Chain (3); Disulfide bond (3); Domain (1); Helix (11); Propeptide (1); Sequence conflict (4); Signal peptide (1); Turn (5) |
| Keywords | 3D-structure;Aspartyl protease;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000305 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1SMR; |
| Mapped Pubmed ID | 10729219; 11145610; 11161799; 11395546; 11457727; 11751275; 12397037; 12512695; 1350294; 1358796; 15253; 15795515; 16446393; 16522658; 1672292; 1673105; 1683707; 1685136; 17083061; 17386351; 17425782; 17630347; 17641813; 17898695; 18424632; 18456730; 18483625; 18486983; 18826488; 19252086; 19293336; 19307186; 19403863; 19531557; 1970330; 19710239; 19749160; 1981051; 20007350; 20462965; 20666571; 20884641; 21078594; 21267068; 21389089; 21565284; 2172970; 22328091; 22526299; 2307472; 25194129; 25224811; 25407269; 2571577; 2574151; 2574991; 26180185; 27754863; 281712; 2833727; 2882954; 2894402; 2895697; 29358217; 2971731; 2993224; 32199017; 32507043; 3384439; 3416634; 3898081; 4042679; 6095203; 6171818; 6327268; 6327270; 6378791; 6389258; 6751556; 6934364; 7028030; 7031061; 7165695; 7692390; 8107115; 8188220; 8203556; 8482578; 8952516; 8952610; 9622149; 9693135; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,283 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |