| IED ID | IndEnz0002007634 |
| Enzyme Type ID | protease007634 |
| Protein Name |
Inactive rhomboid protein 2 iRhom2 Rhomboid family member 2 Rhomboid veinlet-like protein 6 |
| Gene Name | RHBDF2 RHBDL6 |
| Organism | Canis lupus familiaris (Dog) (Canis familiaris) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris) |
| Enzyme Sequence | MDSTDKNGESVSSVSSSRLQSRKPPNLSITIPPPEASAPGEQASMLPQRPRNPAYMKSVSLQEQRGRWQEGSSEKRPGFRRQASLSQSIRKGTAQWFGVSGDWEAKRQHWQRRSLHHCSVRYGRLKASCQRDLELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAPHPPLTPGVLSLTSFTSVRSGHSHLPRRKRMSVAHMSFQAAAALLKGRSVLDATGQRCRVVKRSFAYPSFLEEDVVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGIPRSASPVSPDGVQIPLKEYGRPPVAGTRRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLRNKGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVLRERDLERDSGCCVQNDHSGCIQTQRKDCSETLATFVKWQDDTGPPMDKSDLGQKRTSGAVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAKSNRTGFLHMDCQIKGRPCCISTKGSCEITTREYCEFMHGYFHEEATLCSQVHCLDKVCGLLPFLNPEVPDQFYRLWLSLFLHAGVVHCLVSVVFQMTILRDLEKLAGWHRIAIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFLNLSAIVLFLFICGLLPWIDNIAHIFGFLSGLLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVIWLYVYPINWPWIEYLTCFPFTSRFCEKYELDQVLH |
| Enzyme Length | 827 |
| Uniprot Accession Number | Q00M95 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q80WQ6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Modified residue (6); Region (1); Topological domain (8); Transmembrane (7) |
| Keywords | Cell membrane;Endoplasmic reticulum;Growth factor binding;Membrane;Phosphoprotein;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q80WQ6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80WQ6}. Cell membrane {ECO:0000250|UniProtKB:Q6PJF5}. |
| Modified Residue | MOD_RES 60; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PJF5; MOD_RES 84; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PJF5; MOD_RES 88; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q80WQ6; MOD_RES 294; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q80WQ6; MOD_RES 296; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PJF5; MOD_RES 299; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q6PJF5 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 93,610 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |