| IED ID | IndEnz0002007685 |
| Enzyme Type ID | protease007685 |
| Protein Name |
26S protease regulatory subunit 6A Proteasome regulatory particle ATPase-like protein 5 |
| Gene Name | rpt-5 F56H1.4 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MSQTPPPKDGKNPEAMEVEDAIDEEILKMSTEDLKSRTHLLDNEIRIMRSEVQRINHSATTLKERIKENTERIKVNKTLPYLVSNVVELLDLEDNTEEEGANVDLDAQKTKCAVIKTSTRATYFLPVVGLVDPDELKPGDLVGVNKDSYLILEKLPAEYDSRVKAMEVDERPTEQYSDIGGCDKQIQELIEAVVLPMTHKDRFVNLGIHPPKGVLMYGPPGTGKTMMARAVAAQTKSTFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSEKAGDREVQRTMLELLNQLDGFQPNDDIKVIAATNRIDVLDPALLRSGRLDRKIELPHPNEDARARIMQIHSRKMNVNKDVNFEELARCTDDFNGAQCKAVCVEAGMIALRRDATEILHEDFMDAILEVQAKKKASLNYYA |
| Enzyme Length | 430 |
| Uniprot Accession Number | O76371 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:27528192). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides (By similarity). {ECO:0000250|UniProtKB:P17980, ECO:0000269|PubMed:27528192}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 218..225; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00499 |
| Features | Chain (1); Nucleotide binding (1) |
| Keywords | ATP-binding;Cytoplasm;Nucleotide-binding;Nucleus;Proteasome;Reference proteome |
| Interact With | Q10920; O17071 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10778742; 11099033; 11483502; 11559592; 12437114; 12445391; 12679813; 14551910; 15084750; 15338614; 15489339; 15791247; 15990870; 17392428; 17486083; 17850180; 18182484; 18692475; 19123269; 21085631; 21177967; 21367940; 21529718; 22267497; 22500807; 22560298; 22634595; 22768338; 23604319; 23637632; 23800452; 24884423; 25487147; 25635455; 26009280; 26351692; 26904949; 26952210; 29348603; 31283754; 6593563; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,126 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |