| IED ID | IndEnz0002007727 |
| Enzyme Type ID | protease007727 |
| Protein Name |
Polyporopepsin EC 3.4.23.29 Aspartic proteinase |
| Gene Name | |
| Organism | Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Agaricomycetes Agaricomycetes incertae sedis Polyporales Irpicaceae Irpex Irpex lacteus (Milk-white toothed polypore) (Polyporus tulipiferae) |
| Enzyme Sequence | AAGSVPATNQLVDYVVNVGVGSPATTYSLLVDTGSSNTWLGADKSYVKTSTSSATSDKVSVTYGSGSFSGTEYTDTVTLGSLTIPKQSIGVASRDSGFDGVDGILGVGPVDLTVGTLSPHTSTSIPTVTDNLFSQGTIPTNLLAVSFEPTTSESSTNGELTFGATDSSKYTGSITYTPITSTSPASAYWGINQTIRYGSSTSILSSTAGIVDTGTTLTLIASDAFAKYKKATGAVADNNTGLLRLTTAQYANLQSLFFTIGGQTFELTANAQIWPRNLNTAIGGSASSVYLIVGDLGSDSGEGLDFINGLTFLERFYSVYDTTNKRLGLATTSFTTATSN |
| Enzyme Length | 340 |
| Uniprot Accession Number | P17576 |
| Absorption | |
| Active Site | ACT_SITE 32; ACT_SITE 212 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Milk clotting activity, broad specificity, but fails to cleave 15-Leu-|-Tyr-16 or 16-Tyr-|-Leu-17 of insulin B chain.; EC=3.4.23.29; |
| DNA Binding | |
| EC Number | 3.4.23.29 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (23); Chain (1); Domain (1); Glycosylation (2); Helix (9); Turn (5) |
| Keywords | 3D-structure;Aspartyl protease;Direct protein sequencing;Glycoprotein;Hydrolase;Protease |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1WKR; |
| Mapped Pubmed ID | 15321718; |
| Motif | |
| Gene Encoded By | |
| Mass | 35,051 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |