| IED ID | IndEnz0002007738 |
| Enzyme Type ID | protease007738 |
| Protein Name |
Azurocidin Cationic antimicrobial protein CAP37 Heparin-binding protein HBP pHBP |
| Gene Name | AZU1 |
| Organism | Sus scrofa (Pig) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Suina Suidae (pigs) Sus Sus scrofa (Pig) |
| Enzyme Sequence | MPALRFLALLASLLATSRVGLATLADIVGGRRAQPQEFPFLASIQKQGRPFCAGALVHPRFVLTAASCFRGKNSGSASVVLGAYDLRQQEQSRQTFSIRSISQNGYDPRQNLNDVLLLQLDREARLTPSVALVPLPPQNATVEAGTNCQVAGWGTQRLRRLFSRFPRVLNVTVTSNPCLPRDMCIGVFSRRGRISQGDRGTPLVCNGLAQGVASFLRRRFRRSSGFFTRVALFRNWIDSVLNNPPA |
| Enzyme Length | 246 |
| Uniprot Accession Number | P80015 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. {ECO:0000250|UniProtKB:P20160, ECO:0000269|PubMed:2026172}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (3); Domain (1); Glycosylation (2); Propeptide (2); Signal peptide (1) |
| Keywords | Antibiotic;Antimicrobial;Chemotaxis;Direct protein sequencing;Disulfide bond;Glycoprotein;Heparin-binding;Membrane;Reference proteome;Serine protease homolog;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000250|UniProtKB:P20160}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20160}; Cytoplasmic side {ECO:0000250|UniProtKB:P20160}. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. {ECO:0000250|UniProtKB:P20160}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000250|UniProtKB:P20160 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 27,039 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |