| IED ID | IndEnz0002007760 |
| Enzyme Type ID | protease007760 |
| Protein Name |
Metacaspase-1 EC 3.4.22.- |
| Gene Name | pca1 mca1 SPCC1840.04 |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
| Enzyme Sequence | MSYNSNPYNGGQYPPYNTYTRPNYSPNNGSQSNNTVHQYQPPRMPPPSTRPQTDGNSNQIPMENVGHISLSSANSHAYAPPSGPPPNTGANSYGNPNYSGPQLPNTQTQSYNLAGGGNFQYQYSTCQGKRKALLIGINYLNTQNELQGCINDVMSMSQLLIQRYGYKQEDMVIMTDTASNQRAIPTRQNMLDAMRWLVSDAQPNDALFFHYSGHGGQTKDLDGDEVDGYDETIYPLDHQYAGQIIDDEMHEIMVKPLPAGCRLTALFDSCHSGGALDLPFTYSTKGVLKEPNMLKESGMDVLHAGLSYASGDIMGAINNVKNIFTSATNGFNNNALQYSRQVKFSPADVISLSGCKDNQTSADTSVNGFATGALSYAFREVVTQNPQLSYLQLLRGIRQVLSNKYSQLPQLSCSHPLDMNLAMVL |
| Enzyme Length | 425 |
| Uniprot Accession Number | O74477 |
| Absorption | |
| Active Site | ACT_SITE 214; /evidence=ECO:0000250; ACT_SITE 270; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in cell death (apoptosis). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (3); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Cytoplasm;Hydrolase;Nucleus;Protease;Reference proteome;Thiol protease;Zymogen |
| Interact With | |
| Induction | INDUCTION: Induced by stress-inducing agents such as H(2)O(2), sodium nitroprusside and cadmium chloride. {ECO:0000269|PubMed:17898859}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 15797925; 18653539; 19606215; 20473289; 21670521; 23697806; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,627 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |