| IED ID | IndEnz0002007818 |
| Enzyme Type ID | protease007818 |
| Protein Name |
Cytosolic carboxypeptidase Nna1 EC 3.4.17.- Nervous system nuclear protein induced by axotomy protein 1 homolog |
| Gene Name | Nna1 NnaD CG44533 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MAEREREAMSASLSRLLRTLSSASMSRRHCPLALLQPIPLHQSEIALGSASSGGSAERCCSSCSDDSNNNERCKSAERGTAADEVGEEGREEVELESKEDAVEGEQDELELKRDSSTVNVNVVRANFKCNDMECSLVLGDYVNGFLGSFLSKGLKTNQLVVNTDEKTLRPVARLKEPRDLFALPKDKDNDCSQQAPRWPVECQVIEERIIHIPYVPAVPEPLNAPTGNELKPRPVGEENGIVVFSYSPISAVNYEKPKAKKEDDESSDESDYSSDSRQDSTPPSRSTPMRLAGGGECAPGKLNSVSKMINNVDNRSTSASLDDNDDYYDDEYDTSGGYCGGSGEAKEKAIIKDLIEAKKKRYQEEAEVTPVGGGTARNSRAASRSEASKDASDIDDIWKNNTSEYKPASPRYVLSQFGKNVTKAVIDRIVDHEDLVPPSGSQKVSNQFAVGPVKLPKTNIARLEVAFERSACQDRSKSRLKKKMSSSRRRRESTSDEDSSSSSLGNEEDEEVDDSDSDAENTGSGIGLRRILGSYSARLAGGAEKCPCPGSGSVSDTETLVGDESRSRLAGSNGLHQQDVVCSRNRQAQSRSPLRSVPHTHAATVAAAAAALARGRNRDKDGCLGGKDEKNMGMGVGTTGTSSMGTRTSSPVRNNVFRLSKDQHILLNSMTSQETTGTLISSTSTNQTTTTTNSSQSFLCSDLPQAQFSRSAVGGARFMTNCHPMNPEEYDGLEFESRFESGNLAKAVQITPTYYELYLRPDLYTSRSKQWFYFRVRRTRRKMLYRFSIVNLVKSDSLYNDGMQPVMYSTLGAKEKSEGWRRCGDNICYYRNDDESASSSANEDDEDNSTYTLTFTIEFEHDDDTVFFAHSYPYTYSDLQDYLMEIQRHPVKSKFCKLRLLCRTLAGNNVYYLTVTAPSSNEENMRRKKSIVVSARVHPSETPASWMMKGLMDFITGDTTVAKRLRHKFIFKLVPMLNPDGVIVGNTRNSLTGKDLNRQYRTVIRETYPSIWYTKAMIRRLIEECGVAMYCDMHAHSRKHNIFIYGCENKRNPEKKLTEQVFPLMLHKNSADRFSFESCKFKIQRSKEGTGRIVVWMLGITNSYTIEASFGGSSLGSRKGTHFNTQDYEHMGRAFCETLLDYCDENPNKVKRHAKLFKQIKKIRKREKREQKALKLQKMADQGCIMNDKLKVKRSVEKSVS |
| Enzyme Length | 1201 |
| Uniprot Accession Number | Q9VY99 |
| Absorption | |
| Active Site | ACT_SITE 988; /note=Nucleophile; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.17.- |
| Enzyme Function | FUNCTION: Metallocarboxypeptidase. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Alternative sequence (5); Chain (1); Compositional bias (5); Metal binding (3); Region (6) |
| Keywords | Alternative splicing;Carboxypeptidase;Hydrolase;Metal-binding;Metalloprotease;Mitochondrion;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20620870}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11744370; 14605208; 17099714; 20220848; 20308539; 20371351; 21074052; 23071443; 23087838; 24255095; 25294943; 25996830; 26512413; 27960592; 28241077; 30324448; 30337352; 31630861; 31722958; |
| Motif | |
| Gene Encoded By | |
| Mass | 133,999 |
| Kinetics | |
| Metal Binding | METAL 938; /note=Zinc; /evidence=ECO:0000250; METAL 941; /note=Zinc; /evidence=ECO:0000250; METAL 1034; /note=Zinc; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |