| IED ID | IndEnz0002007833 |
| Enzyme Type ID | protease007833 |
| Protein Name |
Neprilysin-21 EC 3.4.24.- |
| Gene Name | nep-21 T16A9.4 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MKPENGAATWHPAKRSCLGRLTTLETLLLVFLGLLITALLSVLFLWLWVLDGYKTFTDGRPIYPLPFENSSVAVDRSAKNHNDVVCTSRECVRLAGFLAENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRHTISDVQSRLNKQVKSMLQSPISANEKPWDKVAKGYYQKCLDEEELESTGVEAMRDIAKRIGGWPTLEGDKWQEWSHSWEEQIALVLNLTGVNAVILEMAVTHDPSNSSRSVIELDQPKWGAGSRYPYLSGANDPMLRNYTTLMKMTAVALGADPAIAEKEMNEAMEFELKLVNFSADDMVRRDPERGNNRFELWQLKSVFPFINFEKYLKTVFKELVALSPNHTVIVREIDYFVGIQHVLQSTPKRVLANYISWRLVQGFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWEDCVTLSVIMMDMPVGRLFVENFFEKERAMKKMTELTSYLKNEFIKQLHVLDWMDEITRRRAISKANMIEYKSGFPMVLFNDTWMEKNWGMIIKPREYLLHLTIRVKLVRFTEELLRLDQPLDRSMWFQSPAQVDAYYAPNNNEMIFPAGIMQFPFLTLGVPNYITYGMVGAVIGHEVSHAFDDQGGQYDEMGNLNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSNTTGISEPALPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTDVHAPSKYRAMIPLQNRPEFAKAFQCPIGSPMNPERKCQVW |
| Enzyme Length | 769 |
| Uniprot Accession Number | Q22523 |
| Absorption | |
| Active Site | ACT_SITE 602; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; ACT_SITE 667; /note="Proton donor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: Probable cell surface protease. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (5); Domain (1); Glycosylation (10); Metal binding (3); Topological domain (2); Transmembrane (1) |
| Keywords | Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11223883; 11381264; 17164286; 19343510; 20439776; 21177967; 21367940; 22286215; 22347378; 22560298; 23800452; 25487147; |
| Motif | |
| Gene Encoded By | |
| Mass | 88,349 |
| Kinetics | |
| Metal Binding | METAL 601; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 605; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233, ECO:0000255|PROSITE-ProRule:PRU10095"; METAL 663; /note="Zinc; catalytic"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01233" |
| Rhea ID | |
| Cross Reference Brenda |