| IED ID | IndEnz0002007868 |
| Enzyme Type ID | protease007868 |
| Protein Name |
Serine beta-lactamase-like protein LACTB, mitochondrial EC 3.4.-.- |
| Gene Name | LACTB |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MYRLLSAVMARAATTGGCAWGCGRRAAHQRAGLPPLGPGWVGGLGLGLGLALGVKLAGGLRGASPAPPAAAPDPEALPQAEPLQAQEQPLAPWSPQTPAPPHTRHFARAIDSSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVAIAKLWEAGKLDLDIPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDMKKVKEEKAYKALKMMKEMMESDQEKELKEKGGKSNEKNDFAKAKVEQDNETKGRNSKPCKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGLFKNANENLLPGYLKPETMLMIWTPVPNTEMSWDKEGKYAMAWGVVEKKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDAEALNNKVPPRGIVVSIICNMQSVGLNSTALKIALEFDKDRSDIP |
| Enzyme Length | 556 |
| Uniprot Accession Number | P83095 |
| Absorption | |
| Active Site | ACT_SITE 166; /note=Acyl-ester intermediate; /evidence=ECO:0000250|UniProtKB:P15555 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism. It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein. {ECO:0000250|UniProtKB:P83111}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Modified residue (4); Region (1); Transit peptide (1) |
| Keywords | Acetylation;Direct protein sequencing;Hydrolase;Lipid metabolism;Mitochondrion;Protease;Reference proteome;Transit peptide |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11551941}. |
| Modified Residue | MOD_RES 290; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:Q9EP89; MOD_RES 291; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:Q9EP89; MOD_RES 304; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:Q9EP89; MOD_RES 349; /note=N6-acetyllysine; /evidence=ECO:0000250|UniProtKB:P83111 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 61,683 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |