| IED ID | IndEnz0002008012 |
| Enzyme Type ID | protease008012 |
| Protein Name |
des-Arg1-proctolin NEP-inhibiting peptide |
| Gene Name | |
| Organism | Tityus serrulatus (Brazilian scorpion) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus Tityus serrulatus (Brazilian scorpion) |
| Enzyme Sequence | YLPT |
| Enzyme Length | 4 |
| Uniprot Accession Number | P0DUS0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Venom tetrapeptide that inhibits activities of the human peptidase neprilysin (NEP/MME) (Ki=0.94 uM), the two mammalian endopeptidases EP24.16 and EP24.15 (Ki=36 uM and 74 uM, respectively), and a probable cockroach neprilysin-like protein. It shows 3-fold better inhibitory activity than proctolin. It may play a role in human envenomation as well as in the paralysis and death of scorpion preys. It does not inhibit ACE activity. {ECO:0000269|PubMed:26056922}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Peptide (1) |
| Keywords | Direct protein sequencing;Protease inhibitor;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26056922}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 493 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |