| IED ID | IndEnz0002008059 |
| Enzyme Type ID | protease008059 |
| Protein Name |
Aspergillopepsin-2 EC 3.4.23.19 Acid protease A Aspergillopepsin II Proctase A Cleaved into: Aspergillopepsin-2 light chain Aspergillopepsin II light chain ; Aspergillopepsin-2 heavy chain Aspergillopepsin II heavy chain |
| Gene Name | |
| Organism | Aspergillus niger |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus niger |
| Enzyme Sequence | MKFSTILTGSLFATAALAAPLTEKRRARKEARAAGKRHSNPPYIPGSDKEILKLNGTTNEEYSSNWAGAVLIGDGYTKVTGEFTVPSVSAGSSGSSGYGGGYGYWKNKRQSEEYCASAWVGIDGDTCETAILQTGVDFCYEDGQTSYDAWYEWYPDYAYDFSDITISEGDSIKVTVEATSKSSGSATVENLTTGQSVTHTFSGNVEGDLCETNAEWIVEDFESGDSLVAFADFGSVTFTNAEATSGGSTVGPSDATVMDIEQDGSVLTETSVSGDSVTVTYV |
| Enzyme Length | 282 |
| Uniprot Accession Number | P24665 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage in B chain of insulin: 3-Asn-|-Gln-4, 13-Gly-|-Ala-14, and 26-Tyr-|-Thr-27.; EC=3.4.23.19; |
| DNA Binding | |
| EC Number | 3.4.23.19 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (17); Chain (2); Disulfide bond (2); Helix (1); Modified residue (1); Propeptide (2); Region (1); Signal peptide (1); Turn (1) |
| Keywords | 3D-structure;Aspartyl protease;Cleavage on pair of basic residues;Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Pyrrolidone carboxylic acid;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | MOD_RES 110; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:1918059 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1Y43; 3TRS; |
| Mapped Pubmed ID | 22569035; |
| Motif | |
| Gene Encoded By | |
| Mass | 29,887 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |