| IED ID | IndEnz0002008070 |
| Enzyme Type ID | protease008070 |
| Protein Name |
Vitamin K-dependent protein C EC 3.4.21.69 Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV Fragment |
| Gene Name | PROC |
| Organism | Macaca mulatta (Rhesus macaque) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Cercopithecoidea Cercopithecidae (Old World monkeys) Cercopithecinae Macaca (macaques) Macaca mulatta (Rhesus macaque) |
| Enzyme Sequence | EKWELDLDIEEVFIHPNYTKSTTDNDIALLRLAQPATLSQTIVPICLPDSGLAERELTQAGQETLVTGWGYHSSREKEAKRNRTFILNFIKIPVVPRNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGV |
| Enzyme Length | 161 |
| Uniprot Accession Number | Q28506 |
| Absorption | |
| Active Site | ACT_SITE 26; /note=Charge relay system; ACT_SITE 129; /note=Charge relay system |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Degradation of blood coagulation factors Va and VIIIa.; EC=3.4.21.69; |
| DNA Binding | |
| EC Number | 3.4.21.69 |
| Enzyme Function | FUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. {ECO:0000250|UniProtKB:P04070}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (2); Non-terminal residue (2) |
| Keywords | Blood coagulation;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Hemostasis;Hydrolase;Protease;Reference proteome;Secreted;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04070}. Golgi apparatus {ECO:0000250|UniProtKB:P04070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04070}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 17,770 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |