| IED ID | IndEnz0002008142 |
| Enzyme Type ID | protease008142 |
| Protein Name |
Pro-apoptotic serine protease NMA111 EC 3.4.21.- |
| Gene Name | NMA111 HCAG_08651 |
| Organism | Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Histoplasma Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum) Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) |
| Enzyme Sequence | MEMSSKRKHSSGPISLRSTKHLRSDTAASPQPLTPDDQTLGEEAVYVLDNEDEDLSHVLPLAPAAAAQTDSPEWQATIETVVKSVVSIHFCQTASFDTDLSMSSQATGFVVDAEKGYILTNRHVVCAGPFWGYCIFDNHEECDVRPVYRDPVHDFGILKFDPAAIKYMPVTELKLSPDAAKVGVEIRVVGNDAGEKLSILSGVISRLDRNAPEYGEGYSDFNTNYIQAAAAASGGSSGSPVVNIDGHAIALQAGGRADGAATDYFLPLDRPLRALECIRKGVPVTRGTIQTQWIIKPFDECRRLGLSPEWEAAVRKGSPKETGMLVAEIVLPEGPGDGKLQEGDVLIKVNGELLTQFVKLDAILDSSVGKDVHLLVQRGGEDLEVSCTVGDLHAITPARYVTVAGATFHDLSYQQARLYAIACKGVYVCEAAGSFKLENTFSGWIVDTVDKRPTKNLDEFIEVMKTIPDRARVALSYRHIRDLHTRGTSIVHIDRHWHPHIREAIRNDETGLWDFTNIADPLPAEPPVPRKADFIQLDGANHPAAADIVRSFVRVSCTMPVKLDGYPQARKAGFGLVVDAEAGLVLVSRAIVPFDLCDINVTVADSIIVMAKVIFLHPLQNYTIIQYDPSLVQAPVKTARLSTNYIKQGADTIFVGFNQNFRIVVAKTAVTDITTVAIPPNAAAPRYRALNLDAITVDTGLSSQCSNGVLIGEDGIVQALWLNYLGERTASSHKDVEYHLGLATPSLLPIINQIESGSLPKLRIMDMESYVIQMSQARIMGVSEEWIEKVAIANPARHELFMVRKVDCASPLTEDTHQLEEGDIILTLNDKLITRVSEFDIMYHHETLDALIVRNGQEMRVNIKTVPTEDLETDRALIFCGAVLQKPHHAVRQQISKLHSEVYVSARSRGSPAYQYGLSPTNFITAVNGVKTPDLDSFIKQVNVIPNNTYFRLRAVTFDNVPWVVTMKKNDHYFPMSEYIKDPSAPEGWRSISHDKELLRLDSDNLNADAMDEGRDDGISDMEPDGEK |
| Enzyme Length | 1028 |
| Uniprot Accession Number | A6RG85 |
| Absorption | |
| Active Site | ACT_SITE 123; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 154; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 236; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (2); Domain (2); Erroneous initiation (1); Region (3) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 113,146 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |