| IED ID |
IndEnz0002008183 |
| Enzyme Type ID |
protease008183 |
| Protein Name |
pH-response transcription factor pacC/RIM101
|
| Gene Name |
pacC |
| Organism |
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
Eurotiomycetes
Eurotiomycetidae
Onygenales
Arthrodermataceae (dermatophytes)
Trichophyton
Trichophyton rubrum (Athlete's foot fungus) (Epidermophyton rubrum)
|
| Enzyme Sequence |
MQSASSLQQQQPQQQQQQQPQQQGQQQGQQAQQQQGQQQQPASQTVQSVPVQANLQHAAAAAAAVAPPGVQQVAPNSPSAPGSLECQWQGCQELCPTPEALYEHVCERHVGRKSTNNLNLTCGWSNCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLMRSPEPGAGQRQQPPAGMFGVGLGPDGKRSLGPVPQAYGHPPPQYYQPQHPQQQPNPSYGNVYYAVGHDAAHQASYESKKRGYDALNEFFGDLKRRQFDPTSYAAVGQRLLNLHGLPLPLTHAGAVPEYQPMPAMVGVGGGHGGYQSAGPIPTQSYHLPPMGNLRTKADLMNIDQFLEQMQSTVYESDENVAAAGVAQPGAHYVQGPLSYRTTNSPPTHHQSHHQHPHATATAAATTTAATTASMMSTSAAATPASSISAASRSPHASTPALTPPSSAQSYTSGRSPISLASSHGMSPSHHPSTAGMYPTLPATTGQDSLSSSGYPTTVSSAAPPSTLSSVFDDDRRRYTGGMLQRSRPDIDLSTPSIKRDDADATAGKDEPKLSSSVIDPALSRASVDMDEDAAPHRSPSSTPTPTATTAAAGPDDRQPAGEQQWVENVRLLQRLRDYVLERLNNGDYVDEDKQDDSDKEEDAKSDKASPESASASDAATGAGEYPSIKMHGMEAIAAAAVAHEEGRDDQMPRDDEDQENPSTPTARSTTTMLDAEEEAKQAGENLYPVLKMAVDDDGADTDGDEKMGQ |
| Enzyme Length |
758 |
| Uniprot Accession Number |
Q9C1A4 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (6); Motif (2); Region (4); Zinc finger (3) |
| Keywords |
Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Repeat;Repressor;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage by signaling protease (probably palB/RIM13) at neutral to alkaline ambient pH. {ECO:0000250}. |
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 486..489; /note=YPX[LI] motif 1; MOTIF 736..739; /note=YPX[LI] motif 2 |
| Gene Encoded By |
|
| Mass |
80,946 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|