| IED ID | IndEnz0002008211 |
| Enzyme Type ID | protease008211 |
| Protein Name |
Proline iminopeptidase PIP EC 3.4.11.5 Prolyl aminopeptidase PAP |
| Gene Name | PIP At2g14260 T1O16.15 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MNLILASFSLAPCFCVRFFPSNHNNLNLLFPGQRKIQVSCGGKSEVLKSDTMEPHEAETFVNKRTLYAPIEPYSSGNLKVSDVHTLYWEQSGKPDGHPVVFLHGGPGGGTAPSNRRFFDPEFYRIVLFDQRGAGKSTPHACLEENTTWDLVNDIEKLREHLKIPEWLVFGGSWGSTLALAYSQSHPDKVTGLVLRGIFLLRKKEIDWFYEGGAAAIYPDAWEEFRDLIPENERGSSLVDAYHKRLNSDDLEIQYAAARAWTKWEMMTAYLRPNLENVQKAEDDKFSLAFARIENHYFVNKGFFPSDSHLLDNVDKIRHIKTTIVQGRYDVCCPMMSAWDLHKAWPEAELKIVYDAGHSANEPGISAELVVANEKMKALMG |
| Enzyme Length | 380 |
| Uniprot Accession Number | P93732 |
| Absorption | |
| Active Site | ACT_SITE 172; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 329; /evidence=ECO:0000250; ACT_SITE 357; /note=Proton donor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of N-terminal proline from a peptide.; EC=3.4.11.5; |
| DNA Binding | |
| EC Number | 3.4.11.5 |
| Enzyme Function | FUNCTION: Specifically catalyzes the removal of N-terminal proline residues from peptides. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Domain (1); Erroneous initiation (1); Sequence conflict (2) |
| Keywords | Alternative splicing;Aminopeptidase;Cytoplasm;Hydrolase;Protease;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16636467; 18431481; 18650403; 18775970; 26241904; 28627464; 8946961; |
| Motif | |
| Gene Encoded By | |
| Mass | 43,059 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |