| IED ID | IndEnz0002008224 |
| Enzyme Type ID | protease008224 |
| Protein Name |
Signal peptide peptidase-like 5 OsSPPL5 EC 3.4.23.- |
| Gene Name | SPPL5 Os06g0730900 LOC_Os06g51430 B1206D04.13 OsJ_22746 OSJNBa0069C14.36 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MAAATAAVFALLMASALAGAAAGGDIVHHDDEAPKIPGCSNDFILVKVQSWVNGKEDDEYVGVGARFGPQIVSKEKHANRTRLMLADPIDCCTSPKEKVSGDILLVQRGKCKFTKKAKFAEAAGASGIIIINHVHELYKMVCEKNETDLDINIPAVLLPRDAGFALHTVLTSGNSVSVQQYSPDRPVVDTAEVFLWLMAVGTVLCASYWSAWSAREALCEQEKLLKDGREVLLNVENGSSSGMIDINVASAIMFVVVASCFLIMLYKMMSSWFVELLVVIFCVGGVEGLQTCLVALLSRWFRAASESFFKVPFFGAVSYLTLAVSPFCIVFAVLWAVHRHFTYAWIGQDILGIALIITVIQIVRVPNLKVGSVLLSCAFFYDIFWVFVSKRWFHESVMIVVARGDKTDEDGVPMLLKIPRMFDPWGGYSIIGFGDILLPGLLVAFALRYDWAAKKSLQTGYFLWSMVAYGSGLLITYVALNLMDGHGQPALLYIVPFTLGALISLGWKRGELWNLWSKGEPERVCPHHMHMQPQPKTPPLVQ |
| Enzyme Length | 542 |
| Uniprot Accession Number | Q5Z413 |
| Absorption | |
| Active Site | ACT_SITE 382; /evidence=ECO:0000250; ACT_SITE 435; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Glycosylation (2); Motif (1); Signal peptide (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endosome;Glycoprotein;Hydrolase;Membrane;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: Glycosylated. {ECO:0000250}. |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 489..491; /note=PAL |
| Gene Encoded By | |
| Mass | 59,696 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |