| IED ID | IndEnz0002008232 |
| Enzyme Type ID | protease008232 |
| Protein Name |
E3 SUMO-protein ligase SIZ2 EC 2.3.2.- E3 SUMO-protein transferase SIZ2 SAP and Miz-finger domain-containing protein 2 |
| Gene Name | NFI1 SIZ2 YOR156C |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MASVMSNNNNNNNNNNASYMFTNPLSNTGGGLINEIKDAINEMEQLKVLELKQICKSLDLSITGKKAVLQDRIKQFLRKSCDIGHIDPWRPKAIKILIAKVRINSSLPKYSTLWETLKTGAFKHPVASGQLPVTALQSTALPPYSQQQALAYSFTSPFYKPIVQIPDANKKLKQSAGRGCTKMKFKVSKSNHDLLKSNKSYKLYLFSGFSIPFIYETVGHEAIDFPYPCELVFNGTKLEDNVKGLKKQNGTGNPANLTPYLKVPTEMNHLDLHYLNIDKEYSISCFIVEVFSPEALLGKILKRPKIIKQATTAYIKRTLNEQDDDDIITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQNCNEDVEQVEISVDGSWKPIHNSSAVITDTVNQNHSVKNENQGTVKQEQDYDSRNAFDTNLRNGSNHNEPEIISLDSSDDEAFIPASKSFPTHVNPRNDQLRADIFPSESEGSSDYNPNHTSTPKGSPTMDQDNYQDAFQMRSFLNQGATTNINDTPTNNSSINSFVTATNGDSRIFYNRGPSTPLLPAVLQNLTNQTEAQRNPYGPNYNTTAQDRNLLGIEGDLPPIPPVDPNSEAETELPTRTTSAAHLPPYIHVSTSGHGDDGKIRKRRHSNVSIYIPKNPYATLMKRRPQANHAIMNKTLAQTNDFNTSAQDNSEVVDLTSD |
| Enzyme Length | 726 |
| Uniprot Accession Number | Q12216 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 2.3.2.- |
| Enzyme Function | FUNCTION: May act as an E3 ligase mediating SUMO/Smt3 attachment to septins. May be involved in chromosome maintenance. {ECO:0000269|PubMed:11333221, ECO:0000269|PubMed:12761287}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Protein modification; protein sumoylation. |
| nucleotide Binding | |
| Features | Beta strand (14); Chain (1); Compositional bias (1); Domain (2); Helix (7); Metal binding (4); Region (1); Turn (2); Zinc finger (1) |
| Keywords | 3D-structure;Metal-binding;Nucleus;Reference proteome;Transferase;Ubl conjugation;Ubl conjugation pathway;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11587849}. |
| Modified Residue | |
| Post Translational Modification | PTM: Autosumoylated upon ethanol stress. {ECO:0000269|PubMed:15166219}. |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 6U75; |
| Mapped Pubmed ID | 11572779; 11595179; 11743162; 12402242; 12429940; 14660704; 14690591; 14729968; 15161972; 15590687; 15781853; 15870299; 16198156; 16204216; 16554755; 16882975; 17031663; 17077124; 17081974; 17664284; 17888002; 18583943; 18585101; 18701921; 18832349; 19107407; 19139279; 19230795; 19384408; 19536198; 19709431; 19906698; 20351217; 21151918; 21222284; 21666682; 21743457; 21892772; 21968059; 22285753; 22345352; 22562154; 22732495; 22879408; 22964839; 23122649; 23443663; 23550137; 23571759; 23712011; 23812602; 23818500; 23935535; 24130504; 24395824; 24485833; 24500206; 25795125; 26083678; 26253534; 26319015; 26598615; 26783300; 26800527; 26861880; 26921322; 26960795; 27056668; 27130983; 27134164; 27134171; 27215325; 27373152; 27683094; 27799300; 27839712; 31776241; 33929514; 34585421; |
| Motif | |
| Gene Encoded By | |
| Mass | 81,178 |
| Kinetics | |
| Metal Binding | METAL 354; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00452; METAL 356; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00452; METAL 377; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00452; METAL 380; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00452 |
| Rhea ID | |
| Cross Reference Brenda |