| IED ID | IndEnz0002008322 |
| Enzyme Type ID | protease008322 |
| Protein Name |
Mitochondrial intermediate peptidase MIP EC 3.4.24.59 Octapeptidyl aminopeptidase |
| Gene Name | oct1 AFUB_074600 |
| Organism | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) |
| Enzyme Sequence | MKDQLLVPLRRRPWTCQKCLQRLQLPRHQTRRSFETAASPFPRPLDSLPADYARTKTVDDDTLRRVFDSQQFWREFSQQRAAQPKPTGLVQNQYLTSPDGFRTFANVSLQKCQAIVSKVLAASTLEEYRTMARDLDRLSDLLCRVIDLSDFIRVIHPDPQVQEAATQAYALMFEYMNVLNTTTGLNDQLKKAAANPEVTSQWSDEEKIVAQILIKDFSNSAIHMPPHERQRFVNLSNDISQLGSSFVNGAEPAKSHVSVATNNLRGLDPILVQQIKRWNRTAAVPTTGMIPRLALRSVHDENVRREVYLASRTSSKRQLHRLEELLLKRAELAKLSGYESFAHMTLSDKMAKSPEAVSNFLTALVESNRKLVREELSQLQVMKGAPLQPWDHAYYVHQRVLQYSQARRSRELSAVPEFFSLGTVMQGLSRLFDRLYGVRLVPQEPAPGETWNPDVRRLDVVDEAGRHIAVIYCDLFSRPNKHPNPAHFTLRCSREISAEEVAECASLDQSSHPNDGMATAVDPVTQTLRQLPTIALVCDFPEPGTNGGGRPSLLSEHSVRTLFHEMGHAVHSILGQTRLQSISGTRCATDFAELPSVLMEHFATAPSVLALYARHWRTDEPLSEGMIRSMERDRTAHGSIYGAVENEAQILMALVDQAYHSRPADGGRIDSTALYQQVSQQHSSLPEPADATTPPTSWQGFFGHLYGYGATYYSYIFDRAIANKLWVDVFGAGRHAVDRAAGERYKNEVLRWGGGRSGWECVAGALGSANESNADGRLVEGGDQAMREVGRWGLGRDGVSG |
| Enzyme Length | 801 |
| Uniprot Accession Number | B0Y7Q2 |
| Absorption | |
| Active Site | ACT_SITE 565; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.; EC=3.4.24.59; |
| DNA Binding | |
| EC Number | 3.4.24.59 |
| Enzyme Function | FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3); Transit peptide (1) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Mitochondrion;Protease;Transit peptide;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 89,667 |
| Kinetics | |
| Metal Binding | METAL 564; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 568; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 571; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095 |
| Rhea ID | |
| Cross Reference Brenda |