| IED ID | IndEnz0002008394 |
| Enzyme Type ID | protease008394 |
| Protein Name |
Protease PrtH EC 3.4.22.- |
| Gene Name | prtH |
| Organism | Porphyromonas gingivalis (strain ATCC BAA-308 / W83) |
| Taxonomic Lineage | cellular organisms Bacteria FCB group Bacteroidetes/Chlorobi group Bacteroidetes Bacteroidia Bacteroidales Porphyromonadaceae Porphyromonas Porphyromonas gingivalis Porphyromonas gingivalis (strain ATCC BAA-308 / W83) |
| Enzyme Sequence | MHPSTMRCMHLRPVTMHPTSRMLCWKRRLRPKGVRSPEAIRGRIQGTWRQKTVDLPAGTEICCFPSLPKAPICSTSTLMRLRSKTNAKRADFTETFESSTHGEAPAEWTTIDADGDGQGWLCLSSGQLDWLTAHGGTNVVSSFSWNGMALNPDNYLISKDVTGATKVKYYYAVNDGFPGDHYAVMISKTGTNAGDFTVVFEETPNGINKGGARFGLSTEADGAKPQSVWIERTVDLPAGTKYVAFRHYNCSDLNYILLDDIQFTMGGSPTPTDYTYTVYRDGTKIKEGLTETTFEEDGVATGNHEYCVEVKYTAGVSPKKCVNVTVNSTQFNPVKNLKAQPDGGDVVLKWEAPSAKKTEGSREVKRIGDGLFVTIEPANDVRANEAKVVLAADNVWGDNTGYQFLLDADHNTFGSVIPATGPLFTGTASSDLYSANFEYLIPANADPVVTTQNIIVTGQGEVVIPGGVYDYCITNPEPASGKMWIAGDGGNQPARYDDFTFEAGKKYTFTMRRAGMGDGTDMEVEDDSPASYTYTVYRDGTKIKEGLTETTYRDAGLSAQSHEYCVEVKYTAGVSPKVCVDYIPDGVEDVTVQKPHTLTVVGKTITVSWQGEAMIYDMNGRRLAAGRNTVVYTAQGGYYAVMVVVDGKSYVEETRYQVNLSWTRRLCADTSKHRSVIVSEYESVARPPFKEVGRLRFYAYYSNILLKQFVPKSCMKRLSYYLPHCKKGSFLRFPRSSTVITVCQFSWLEYLPVTQGVAGSSPVHTAKIRSCVEIVFRHSSIFVCYRSTGKYNYRMRLFNMLGKNFLRTKQKCLSLLRSAWDIGIKLVLFQEGRYMESPGQSDEERRTTIDFYGNGRYLLFRHSELLVENGYQVKAVVTMLGTKPMGRGHKVSPSMVKLYAQELGLPILQPDNLNEESFLDELRTYQPHLQIVVAFRMLPRSVWQMPPMGTINLHGSLLPMYRGAAPIQPRDTPWRYGKRELPPSASGMR |
| Enzyme Length | 989 |
| Uniprot Accession Number | P46071 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Cleaves human complement component C3. May enable P.gingivalis to evade complement-mediated killing during the immune response. Plays an important role in soft tissue infections and is a virulence factor. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Region (1); Repeat (2) |
| Keywords | Cytoplasmic vesicle;Hydrolase;Protease;Repeat;Thiol protease;Virulence |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=In membrane vesicles. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 110,238 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |