| IED ID |
IndEnz0002008441 |
| Enzyme Type ID |
protease008441 |
| Protein Name |
26S proteasome regulatory subunit RPN11
|
| Gene Name |
RPN11 ECU11_0570 |
| Organism |
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Fungi incertae sedis
Microsporidia
Apansporoblastina
Unikaryonidae
Encephalitozoon
Encephalitozoon cuniculi (Microsporidian parasite)
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
|
| Enzyme Sequence |
MFSGFVGPDDGEPTSDASETVQISSLALLKMLKHGRAGIPLEVMGLMLGEFVDEYTVKVVDVFAMPQSGTNVTVESVDPIFQMEMMSILKATGRHETVVGWYHSHPGFGCWLSTVDISTQQSFEKLCKRAVAVVVDPIQSVKGKVVIDAFRLIDNQLGVLGGEPRQVTSNIGYLKTPTLISIIHGLNKHYYSFNITCRKNDFEQKMLLNLHRKTWADNLKLGDVRSKREEALKLIESYGKAFEEEKNLAGKNPDMAKVGRIDYRRRLLEKCEESIMENTIYSLLYSIHRYIFTQ |
| Enzyme Length |
294 |
| Uniprot Accession Number |
Q8SQY3 |
| Absorption |
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| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity). {ECO:0000250}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Domain (1); Metal binding (3); Motif (1) |
| Keywords |
Cytoplasm;Hydrolase;Metal-binding;Metalloprotease;Nucleus;Protease;Proteasome;Reference proteome;Zinc |
| Interact With |
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| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
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| Post Translational Modification |
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| Signal Peptide |
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| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 103..116; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By |
|
| Mass |
33,173 |
| Kinetics |
|
| Metal Binding |
METAL 103; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 105; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 116; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID |
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| Cross Reference Brenda |
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