| IED ID | IndEnz0002008446 |
| Enzyme Type ID | protease008446 |
| Protein Name |
Signal peptide peptidase 1 OsSPP1 EC 3.4.23.- Intramembrane protease 1 IMP IMPAS |
| Gene Name | SPP1 Os02g0117400 LOC_Os02g02530 OJ1442_E05.26 OsJ_05128 |
| Organism | Oryza sativa subsp. japonica (Rice) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae Liliopsida Petrosaviidae commelinids Poales Poaceae BOP clade Oryzoideae Oryzeae Oryzinae Oryza Oryza sativa (Rice) Oryza sativa subsp. japonica (Rice) |
| Enzyme Sequence | MKTHERAANLALAGLSLAPLVVKVEPNVNVILTACLAVYVGCYRSVKPTPPSETMSKEHAMRFPLVGSAMLLSLFLLFKFLSKDLVNAVLTAYFFILGIAALCATLLPSIKRFLPKEWNDNAIVWCAPFFHSLSVEFTKSQVVASIPGFFFCIWYAAKKHWLANNVLGISFCIQGIEMLSLGSFKTGAILLAGLFFYDIFWVFFTPVMVSVAKSFDAPIKLLFPTGDAARPFSMLGLGDIVIPGIFVALALRFDVSRGIKNRYFNSAFLGYTVGLTVTIIVMNWFQAAQPALLYIVPGVIGFVAVHCLWNGEVKPLLEYNESKAEEEDAVEEDTDSKQNKKEE |
| Enzyme Length | 343 |
| Uniprot Accession Number | Q6ZGL9 |
| Absorption | |
| Active Site | ACT_SITE 198; /evidence=ECO:0000250; ACT_SITE 239; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Motif (2); Region (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19688213}; Multi-pass membrane protein {ECO:0000269|PubMed:19688213}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 290..292; /note=PAL; MOTIF 340..343; /note=Endoplasmic reticulum targeting signal; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 37,922 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |