| IED ID | IndEnz0002008474 |
| Enzyme Type ID | protease008474 |
| Protein Name |
Protease 4 EC 3.4.21.- Endopeptidase IV Protease IV Signal peptide peptidase |
| Gene Name | sppA HI_1541 |
| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pasteurellales Pasteurellaceae Haemophilus Haemophilus influenzae Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
| Enzyme Sequence | MFQVLKFCWKVLCFIRDLVMNVVFLGFVLLLVAIISFSSGGKKSTALTSEGALLLNLDGYLADNRDETLRWQDALSELNGEHVPRKISTFDVVFAIQQAEDDPKIKGLVLDLNYFEGADLPALDFIGGAISHFKDAGKPVIAYADNYSQGQYYLASFADEIYLNSIGSVDIHGLSQENLYFKEMLDKLAVTPHIFRVGTYKSAVEPFLRNDMSAEAKANMQRWLGEMWNNYVLSVSENRNIKKDRILPNAKQYLAELKALKGNSTAYAQQRGLVTDVVTRLDLDKKLSALFGKGSDGKANLIEFDDYLTQLPDRLEHYNVPNKIAVVNVEGTIIDGESDEENAGGDTIARILRKAHDDNSVKAVILRVNSPGGSAFASEIIRQETENLQKIGKPVIVSMGAMAASGGYWISSTADYIIADSNTITGSIGIFTMFPTFENSIKKIGVHADGVSTTELANTSAFSPLAKPVQDIYQTEIEHGYDRFLEIVSKGRQLSKTQVDKLAQGQVWLGSDAFQNGLVDEIGSFNEAVNKAEQLVNQRQDTAVQDFSVEWFTDDNVSLISTLLSDTKKGAQEQLVKWLGLPAPIQKLQKELNILTKFNDPKGQYLYCLNCGKVK |
| Enzyme Length | 615 |
| Uniprot Accession Number | P45243 |
| Absorption | |
| Active Site | ACT_SITE 201; /note=Proton donor/acceptor; /evidence=ECO:0000250; ACT_SITE 405; /note=Nucleophile; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell inner membrane;Cell membrane;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 68,057 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |