| IED ID | IndEnz0002008495 |
| Enzyme Type ID | protease008495 |
| Protein Name |
Metacaspase-1A EC 3.4.22.- |
| Gene Name | casA AFUB_007090 |
| Organism | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus) |
| Enzyme Sequence | MQNHHHQQSSYGGGYPGQAYREQHPPPNPYGYGQPSPQPGYGAPPPHNGYGQPPSGYGQPPPPTGNAVYGGRQPGMNQYQNTYSHGHQGGPPPPPTDPVAFGHGAPQGYSFQYSRCTGKRKALLIGINYFGQKGQLRGCINDVKNMSTYLNQNFGYAREDMVLLTDDQQNPMSQPTKANILRAMHWLVKDAQPNDSLFFHYSGHGGQTPDLDGDEEDGYDEVIYPVDFRQAGHIVDDEMHRIMVRPLRPGVRLTAIFDSCHSGSALDLPYIYSTQGILKEPNLAKEAGQGLLGVVSAYARGDMSGMVSTAVGFLKRATKGDEAYTRSKQTKTSPADVIMWSGSKDSQTSQDAQIGGQATGAMSWAFITALRKNPQQSYVQLLNSIRDELATKYSQKPQLSCSHPLDTNLLYVM |
| Enzyme Length | 413 |
| Uniprot Accession Number | B0XPP3 |
| Absorption | |
| Active Site | ACT_SITE 204; /evidence=ECO:0000250; ACT_SITE 260; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Involved in cell death (apoptosis) (By similarity). Required for the apoptotic-like loss of membrane phospholipid asymmetry at stationary phase and facilitates growth under conditions of endoplasmic reticulum stress. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (2); Erroneous gene model prediction (1); Propeptide (1); Region (1) |
| Keywords | Apoptosis;Hydrolase;Protease;Thiol protease;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,199 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |