| IED ID | IndEnz0002008580 |
| Enzyme Type ID | protease008580 |
| Protein Name |
Inactive rhomboid protein 1 iRhom1 Rhomboid family member 1 |
| Gene Name | rhbdf1 zgc:91984 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MAELRRDSTSSLQRKKPPWLKLDIPTAHVSVDEVPAFVPPVKRQGFHRSASMPVETSHFHSPQRDIIDHRRAAFQRQSSITQTIKRGTADWFGVSKDGDATQKWQRKSLRHCSLRYGKLKPQVIREMELPSQDNISLTSTETPPPLYVPSSQHGMQKIVDPLARGRAFRMVEEVDGYSVPQTPITPGAASICSFNSSRSGLNRIPRRRKRESVAKMSFRAAAALVKGRSLREGTLRRAHRRSFTPASFIEEDVVDFPDELDTSFFARDIMMHEEMSTFHDEVFESPSDSTMKDVDSKQLDESELTGSALDKSELEKSHLMLPLERGWRKVKEKTPAPPKIRLKQEVVSVNGQRRGQRIGLPVKKLFAREKRPYGLGMVGKLTNRTYRKRIDSYVKKQIEDMDDHRPFFTYWITFVHILITILAVCIYGIAPVGFSQHETVDSVLRNKGVYENVKFVQQENFWIGPSSEALIHLGAKFSPCMRRDNQVHELIKKKQELERNSACCVRNDRSGCLQTSEEECSSTLAVWVKWPQHPSVPQLDGVARQHGSVCHQDPRTCTEPASVSPHEWPDDITKWPICTKYNSGNHTNLPHIDCTITGRPCCIGTKGRCEITSREYCDFMKGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSVCFQMTILRDLEKLAGWLRISIIYILSGITGNLASAIFLPYRAEVGPAGSQFGILACLFVELIQSWQILAQPWRAFTKLLCVVLFLFAFGLLPWIDNFAHISGFISGFFLSFAFLPYISFGRLDMYRKRCQIIIFLVVFLGLFAGLVVLFYVHPIKCEWCELLTCIPFTDKFCEKYDLNAHLH |
| Enzyme Length | 857 |
| Uniprot Accession Number | Q6GMF8 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. {ECO:0000250|UniProtKB:Q96CC6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Glycosylation (1); Region (1); Topological domain (8); Transmembrane (7) |
| Keywords | Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Growth factor binding;Membrane;Protein transport;Reference proteome;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96CC6}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q96CC6}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 97,841 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |