| IED ID | IndEnz0002008641 |
| Enzyme Type ID | protease008641 |
| Protein Name |
Pro-apoptotic serine protease NMA111 EC 3.4.21.- |
| Gene Name | NMA111 ABR134C |
| Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Eremothecium Eremothecium gossypii (Yeast) (Ashbya gossypii) Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
| Enzyme Sequence | MTIQAHKRTLSEVSTSSVGQLKRREGYTEDYTDEGSDIDMPEYVTDSANNQQWQDTISRVVQSVVSVHFAQVAPFDCESALVSEATGFVVDAKLGIILTNRHVVGAGPFSGYAVFDNHEECDVIPIYRDPVHDFGFLKFDPSTIKYMNVQALELKPALAKVGSEIRVVGNDAGEKLSILAGFISRVDRNAPDYGELTYNDFNTEYIQAAAAASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALRCIQGSQPITRGTIQTQWLLKPYDECRRMGLSPESEAKAREQFPGKIGLLVAETILREGPADKSIKEGDILISINGQMICSFIQVDAILDENVGKPITLVVQRSGIDITVECTVGDLHAITPSRYVEVCGATFNELSYQMARYYAIPVRAVFLSSATGSFCFDTKEKLGWIVDEVNNQPTPTLDTFIEVMSTIPDCSRVTVQYHHLVDQHSPHVTTVYIDRHWCNEFRIFERNDETGIWDYKNLADPIPALPLKPQTAKFIDLPISNPKLARLARMLVMVSTIGPVPLDSVDPEPRKAAGLVLDAKQGYVIVSRRIVPHDCMDVFVTIAESVLVPASVVFLHPTQNYVIVKYDPAQVQAAVETPILSTERLKRGDKVQFVGYTHNFRSVSSETTVTDISSLSIPSNMVPRYRATNLEAISIESSVGSRCHSGILADDDGTVRALWLSFLGEKQDEKDKIYLMGLDLVDIGEVVEVLKKGKIPRVNIVDSGFGSISVLQARLRGVPEEWIKRMESESENRLQFITVTRVSYTDEEQKLVSGDIILSVNDQLVKQMRDLEGIVTTTDVPAVQQVLRFKIVRKGSIMDLDIKTIEVEETSKIVIFAGCILQAPHHAVRQAMLNIPSGVYCTFRGQSSPAIQYGISSTNFITHVNEIETPDLDRFLEVVRTIPDNTYCKIRLVTFDNVPFAISLKTNYHYFPTSELSRNSDTGRWIEHLCNATPAKN |
| Enzyme Length | 977 |
| Uniprot Accession Number | Q75D90 |
| Absorption | |
| Active Site | ACT_SITE 102; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 133; /note=Charge relay system; /evidence=ECO:0000255; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Nuclear serine protease which mediates apoptosis. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Domain (2); Region (2) |
| Keywords | Apoptosis;Hydrolase;Nucleus;Protease;Reference proteome;Repeat;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 108,313 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |