| IED ID |
IndEnz0002008666 |
| Enzyme Type ID |
protease008666 |
| Protein Name |
pH-response transcription factor pacC/RIM101
|
| Gene Name |
pacC FOXG_02222 |
| Organism |
Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Pezizomycotina
leotiomyceta
sordariomyceta
Sordariomycetes
Hypocreomycetidae
Hypocreales
Nectriaceae
Fusarium
Fusarium oxysporum species complex
Fusarium oxysporum (Fusarium vascular wilt)
Fusarium oxysporum f. sp. lycopersici
Fusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato)
|
| Enzyme Sequence |
MSPPAPEQKPQLQQQQQQGSSSGDSSSGSANDSKSVTPAPSATSNTSQSSTAPSTSSDDNLICRWNACNQKFPAPEALYEHICERHVGRKSTNNLNLTCQWNSCRTTTVKRDHITSHIRVHVPLKPHKCEFCGKSFKRPQDLKKHVKTHADDSVLVRPSQDPQGGLNYRPQPPKGPSSYYDHTGQMRTNAAAFAHQAGHPSGGYYAPQPSTNYGLYFNQPPINNARTEHLGYSAAAGGYDRKRTYDMVDDFFGSAKRRQIDPSSYAQIGRSLMPLHGNLSVPNGPMTATEQYMPQPAPAPVHAGPTPSKTPSAQQYYLPMPSARTQKDLIHIDTILGQMQDTIYENANHATAGVHIHHAENGFNGYRNTPSPPTSHRSPTGMHVGADGYQPVSAASMASPLTAISSTGTPAVTASSSMSYTSGHSPSPSSSAMSPQSRHGSTASVMYPTLPTSLPAVSQGFGHSATTTLGPSFDGSERRRYSGGMLQRARAGPLPLPHEDTSGASTPKASESALSVGSPSSESDVSDATREREEQYDRWLENMRVIETLREYVRGRLERKEFVDDNESPRSSHSDAMDVDPKSPQAPPRELGTPREGSSLYPILRMPGA |
| Enzyme Length |
609 |
| Uniprot Accession Number |
Q870A3 |
| Absorption |
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| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
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| Enzyme Function |
FUNCTION: Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including pacC itself) and represses transcription of acid-expressed genes. Specifically recognizes and binds the consensus sequence 5'-GCCARG-3'. May act as a negative regulator of virulence to plants. {ECO:0000269|PubMed:12694620}. |
| Temperature Dependency |
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| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (4); Motif (2); Region (5); Zinc finger (3) |
| Keywords |
Activator;Cytoplasm;DNA-binding;Metal-binding;Nucleus;Reference proteome;Repeat;Repressor;Transcription;Transcription regulation;Zinc;Zinc-finger |
| Interact With |
|
| Induction |
INDUCTION: By alkaline conditions and during infection of tomato roots. {ECO:0000269|PubMed:12694620}. |
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Activated by C-terminal proteolytic cleavage. At neutral to alkaline ambient pH, the signaling protease cleaves pacC within the conserved 24-residue signaling protease box. In an ambient pH-independent reaction, the processing protease (probably the proteasome) removes additional C-terminal residues to yield the functional form. {ECO:0000269|PubMed:12694620}. |
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
MOTIF 447..450; /note=YPX[LI] motif 1; MOTIF 601..604; /note=YPX[LI] motif 2 |
| Gene Encoded By |
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| Mass |
65,832 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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