| IED ID | IndEnz0002008682 |
| Enzyme Type ID | protease008682 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 2 homolog A 26S proteasome regulatory subunit RPN1a AtRPN1a 26S proteasome regulatory subunit S2 homolog A |
| Gene Name | RPN1A At2g20580 F23N11.10 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MAPTQDPNSVGGGAKKDEATLKVPSKDPKKKDEKKDEDLSEEDLELKQNLELYVERVQDPNPELQKAALESMRQEIRASTSSMTSVPKPLKFLRPHYGTLKAFHETMADSDLKKYLSDILSVLALTMSADGERESLRFRLIGTEGDIGSWGHEYVRNLAGEIAQEYTKRQSEEASIDDLMELVQQIVAFHMKHNAETEAVDLLMDVEDLDLLLEHVDKTNFKRTCNYLTSAARYLPGPDDMLVLDISYMIYMKFEEYPNALQIALFLDNTQYVKQVFTSCTDLLKKKQFCYMIARHGITFELDDEMVADDDDREALQDIVNNTKLSEGYLTLARDIEVMEAKTPEDIYKAHLLDGRASSGASVDSARQNLAATFVNAFVNAGFGQDKLMTVPSDSTTGSSGNWLFKNKEHGKTSAAASLGMIQLWDVDSGLSQLDKYFHSNDNPIIAGALLGVGIVNCGIKNDCDPALALLGDYIDKEDSSVRIGAIMGLGISYAGSQNDQIRNKLSPILNDAKAPLDVIAFASLSLGMIYVGSCNEEVAQSIIFALMDRSEAELGDALTRFLPLGLGLLYLGKQESVEATAEVSKTFNEKIRKYCDMTLLSCAYAGTGNVLKVQDLLAQCGEHLEKGDIHQGPAVLGLAMVAMSEELGVDMEIRSLERMLQYGEQNIRRAVPLALGLLCISNPKVTVMDTLSRLSHDTDSEVAMSAIISLGLIGAGTNNARIAGMLRNLSSYYYKDMSLLFCVRIAQGLVHMGKGLLTLSPFHSERFLLSPTALAGIVTLLHACLDMKPIILGKYHYVLYFLVLAMQPRMMLTVDENLKPLSVPVRVGQAVDVVGQAGRPKTITGFQTHSTPVLLAAGERAELATDKYIPLSPILEGFIILKENPDYREE |
| Enzyme Length | 891 |
| Uniprot Accession Number | Q9SIV2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). Required during embryogenesis (PubMed:16169895). Required for optimal plant growth and stress responses (PubMed:19605416). Required for innate immunity (PubMed:22577987). {ECO:0000250, ECO:0000269|PubMed:16169895, ECO:0000269|PubMed:19605416, ECO:0000269|PubMed:22577987}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Cross-link (1); Erroneous initiation (1); Modified residue (1); Region (1); Repeat (7) |
| Keywords | Acetylation;Cytoplasm;Immunity;Innate immunity;Isopeptide bond;Nucleus;Proteasome;Reference proteome;Repeat;Ubl conjugation |
| Interact With | |
| Induction | INDUCTION: By salicylic acid (SA). {ECO:0000269|PubMed:22577987}. |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22577987}. Cytoplasm {ECO:0000269|PubMed:22577987}. |
| Modified Residue | MOD_RES 219; /note=O-acetylthreonine; /evidence=ECO:0000269|PubMed:20516081 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10363660; 11742986; 12000681; 17028202; 17317660; 17426018; 17675552; 17825468; 18642946; 19874541; 20706207; 21798944; 22010978; 23653471; 25676129; 27247031; 27474935; 28627464; 29487187; 9741626; |
| Motif | |
| Gene Encoded By | |
| Mass | 98,144 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |