| IED ID | IndEnz0002008699 |
| Enzyme Type ID | protease008699 |
| Protein Name |
Vitamin K-dependent protein C EC 3.4.21.69 Anticoagulant protein C Autoprothrombin IIA Blood coagulation factor XIV Fragment |
| Gene Name | PROC |
| Organism | Equus caballus (Horse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Perissodactyla (odd-toed ungulates) Equidae (horses) Equus Equus Equus caballus (Horse) |
| Enzyme Sequence | ENGEVDLDIQEVIMHPNYSKSSSDNDIALLRLARPATFSQTIVPICLPDSGLSERELTQAGQETVVTGWGYRSETKRNRTFVLNFIKVPVVPHSECVRTMHNLVSENMLCAGILGDTRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRLHNYGV |
| Enzyme Length | 157 |
| Uniprot Accession Number | Q28380 |
| Absorption | |
| Active Site | ACT_SITE 26; /note=Charge relay system; ACT_SITE 125; /note=Charge relay system |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Degradation of blood coagulation factors Va and VIIIa.; EC=3.4.21.69; |
| DNA Binding | |
| EC Number | 3.4.21.69 |
| Enzyme Function | FUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. {ECO:0000250|UniProtKB:P04070}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Domain (1); Glycosylation (2); Non-terminal residue (2) |
| Keywords | Blood coagulation;Disulfide bond;Endoplasmic reticulum;Glycoprotein;Golgi apparatus;Hemostasis;Hydrolase;Protease;Reference proteome;Secreted;Serine protease |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04070}. Golgi apparatus {ECO:0000250|UniProtKB:P04070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04070}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 17,200 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |