| IED ID | IndEnz0002008728 |
| Enzyme Type ID | protease008728 |
| Protein Name |
Sortilin-related receptor Low-density lipoprotein receptor relative with 11 ligand-binding repeats LDLR relative with 11 ligand-binding repeats LR11 SorLA-1 Sorting protein-related receptor containing LDLR class A repeats SorLA Fragment |
| Gene Name | SORL1 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | GWVSLNDSHNQMVVHWAGEKSNVIVALARDSLSLLGPKNSDVYISYDYGKSFKKISERFSFGDGNSSAVAIAQFYHSPANNQRYIFVDAFVPYLWITTDFCKSIQGFSIPFRAADLLLHSRNPNLVLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGVEPYDKPNTVYIERHEPSGTSTVIRSTDFFQSRENKEVILEDVDDFQLRDKYLFATKAVRLLGSLQPSSVQLWVSFNRKPMRVAQFVTKHPIKEYYIADASEDQVFVCVSHDDNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGVRGVYIATLLNGSFSEENMRSVITFDKGGTWEPLQPPAETRYGEKTHCELSQGCSLHLAQRLSQLLNFQLRRMPILSKESAPGLIIATGSIGKSMAKKTNVYISSSAGARWREALSGPHYYTWGDHGGILVAIAQGTETDQLKYSTNEGETWKSFTFSEKPVFVYGLLTEPGEKSTIFTIFGSYKENGHSWLILQVNTSDVLGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVMVSNCSCTREDFECDFGFKLSEDLSLEVCVPDPEFAGKPYDPPVPCPVGSTYRRTRGYRKISGDTCMGGDIESRLEGEMLPCPLAEENEFILYATRYSIHRYDLASGLSQELPLAGLRGAVALDFDYEHNCLYWADVTLDIIQRLCLNGSSGQEIIISTGLETVEALAFEPLSQLLYWVNAGIPKIEVANPDGDLRLTVLNSSVLERPRALALVPREGLMFWTDWGDSRPGIYRSDMDGSLAACIVSEGVRWPNGISVDDHWIYWTEAYMDRIERVDFNGLQRSVILDSLPHPYAIAVFKNEIYWNDWSQLSIFRASKNSGSRMETLVGRLYGIMDMKIFYRGKTTGQNACIAHPCSLLCLPKSNNGRSCKCPEGVSSTVLPSGEVKCDCPHGYSMKNNTCVKEENTCLPNQYRCFNGNCINSIWQCDNNNDCGDMSDEKNCPTTVCDAETQFRCRESGTCIPLSYKCDLEDDCGDNSDESHCEAHQCRKDEFSCSSGMCIRLSWRCDDDNDCRDWSDEANCTMFRTCEASSFQCLNGHCIPQRWACDGDADCQDGSDEDPTICEKKCNGFQCPNGTCISTSKHCNGITDCADASDEQDCEIPLCTRYMDFVCKNRQQCLSHSMVCDGDIQCEDGSDEDANYAGCAQEPEFHRTCDQFSFQCANGVCISLVWKCDGMDDCGDYSDEASCENPTDAPTCSRYYQFQCGNGHCIPNQWKCDGENDCGDWSDEKECEGSPLLPITTAVPPTCLPNHFRCGSGACITNSWVCDGYRDCADGSDEDACPTSHPNVTSSPPAPRGRCSRTEFECQQLHKCIPNWKRCDGRRDCQDGTDERSCPTHSSLSCPQGYRCEDGEACLLATERCDGYLDCSDGSDERNCTDDTIVYKVQNLQWTADFSGAITLTWARPKRMSSTSCVYNVYYRMVGESIWKVLETHSNKTSSVLKVLKPDCTYQVKVQVQCLSRVYNTNDFITLRVPEGLPDAPFNLQLALKKEAEGVVLCSWSAPVNAHGLIREP |
| Enzyme Length | 1592 |
| Uniprot Accession Number | Q98930 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (By similarity). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (By similarity). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling (By similarity). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (By similarity). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (By similarity). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue (By similarity). Plays a role in renal ion homeostasis, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR, hence facilitating the proteolysis of the extracellular matrix (By similarity). May also stimulate the proliferation, adhesion and migration of monocytes/macrophages (By similarity). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (By similarity). May regulate IL6 signaling (By similarity). {ECO:0000250|UniProtKB:O88307, ECO:0000250|UniProtKB:Q92673}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (33); Domain (14); Glycosylation (14); Non-terminal residue (2); Repeat (10) |
| Keywords | Cell membrane;Cytoplasmic vesicle;Disulfide bond;EGF-like domain;Endocytosis;Endoplasmic reticulum;Endosome;Glycoprotein;Golgi apparatus;Membrane;Receptor;Reference proteome;Repeat;Secreted;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Endosome membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Early endosome membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Cell membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q92673}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92673}. Secreted {ECO:0000250|UniProtKB:Q92673}. Note=Mostly intracellular, predominantly in the trans-Golgi network (TGN) and in endosome, as well as in endosome-to-TGN recycling compartments; found at low levels on the plasma membrane. At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu. Following shedding, may be cleaved the remaining transmembrane fragment and catalyzes the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus. At the cell surface, the full-length protein undergoes partial clathrin-dependent endocytosis guided by the clathrin adapter protein 2 (AP-2). {ECO:0000250|UniProtKB:Q92673}. |
| Modified Residue | |
| Post Translational Modification | PTM: Within the Golgi apparatus, the propeptide is cleaved off by FURIN or a furin-like protease. At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu. Following shedding, may be cleaved the remaining transmembrane fragment and catalyze the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus. {ECO:0000250|UniProtKB:Q92673}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 178,411 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |