| IED ID | IndEnz0002008751 |
| Enzyme Type ID | protease008751 |
| Protein Name |
Kunitz-type protease inhibitor 2 Hepatocyte growth factor activator inhibitor type 2 HAI-2 Placental bikunin |
| Gene Name | SPINT2 HAI2 KOP |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL |
| Enzyme Length | 252 |
| Uniprot Accession Number | O43291 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (4); Chain (1); Disulfide bond (6); Domain (2); Glycosylation (2); Helix (1); Natural variant (2); Region (1); Sequence conflict (4); Signal peptide (1); Site (2); Topological domain (2); Transmembrane (1); Turn (2) |
| Keywords | 3D-structure;Alternative splicing;Direct protein sequencing;Disease variant;Disulfide bond;Glycoprotein;Membrane;Protease inhibitor;Reference proteome;Repeat;Serine protease inhibitor;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:9115294" |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 4U32; |
| Mapped Pubmed ID | 11013244; 11777908; 12180971; 12211652; 12522575; 12553733; 12569552; 12571229; 1280830; 14558597; 14695180; 14734471; 15324701; 15388859; 15717269; 15792801; 15930277; 16140784; 16353247; 17255277; 18358501; 18689863; 18713750; 1885621; 19047176; 19107935; 19148468; 20009592; 20063316; 20228799; 20687215; 20715109; 21875933; 21898507; 22087277; 23293962; 24121274; 24142340; 24269829; 24409221; 24410667; 24722141; 25301953; 25786220; 25852190; 25910030; 26030814; 26171609; 26442953; 26684320; 27737800; 28371047; 28710277; 28817220; 29118397; 29438412; 29575628; 29843210; 29987920; 30445423; 30484958; 30765871; 31701492; 32056846; 33547739; 33789993; 34181691; 34299087; 34381422; 8346233; 9045658; |
| Motif | |
| Gene Encoded By | |
| Mass | 28,228 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |