| IED ID | IndEnz0002008775 |
| Enzyme Type ID | protease008775 |
| Protein Name |
26S proteasome regulatory subunit 4 homolog Tat-binding homolog 5 |
| Gene Name | RPT2 YHS4 YTA5 YDL007W D2920 |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MGQGVSSGQDKKKKKGSNQKPKYEPPVQSKFGRKKRKGGPATAEKLPNIYPSTRCKLKLLRMERIKDHLLLEEEFVSNSEILKPFEKKQEEEKKQLEEIRGNPLSIGTLEEIIDDDHAIVTSPTMPDYYVSILSFVDKELLEPGCSVLLHHKTMSIVGVLQDDADPMVSVMKMDKSPTESYSDIGGLESQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRIVGSELIQKYLGDGPRLCRQIFKVAGENAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDDRGDVKVIMATNKIETLDPALIRPGRIDRKILFENPDLSTKKKILGIHTSKMNLSEDVNLETLVTTKDDLSGADIQAMCTEAGLLALRERRMQVTAEDFKQAKERVMKNKVEENLEGLYL |
| Enzyme Length | 437 |
| Uniprot Accession Number | P40327 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Has ATPase activity. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 223..230; /note=ATP; /evidence=ECO:0000255 |
| Features | Chain (1); Compositional bias (1); Cross-link (3); Initiator methionine (1); Lipidation (1); Mutagenesis (1); Nucleotide binding (1); Region (1); Sequence conflict (1) |
| Keywords | 3D-structure;ATP-binding;Cytoplasm;Direct protein sequencing;Isopeptide bond;Lipoprotein;Myristate;Nucleotide-binding;Nucleus;Proteasome;Reference proteome;Ubl conjugation |
| Interact With | P38764; P43588; P33299 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (27) |
| Cross Reference PDB | 3JCO; 3JCP; 4CR2; 4CR3; 4CR4; 5A5B; 5MP9; 5MPA; 5MPB; 5MPC; 5WVI; 5WVK; 6EF0; 6EF1; 6EF2; 6EF3; 6FVT; 6FVU; 6FVV; 6FVW; 6FVX; 6FVY; 6J2C; 6J2N; 6J2Q; 6J2X; 6J30; |
| Mapped Pubmed ID | 10363642; 10559920; 10664589; 11430818; 11742986; 11805826; 11805837; 11884593; 12477387; 1429620; 14690591; 14759368; 15135049; 15210724; 15571806; 15699485; 15905137; 16284124; 16429126; 16554755; 16922378; 17499717; 17803938; 17889660; 18174173; 18467557; 19013276; 19412160; 19446322; 19446323; 19516331; 19536198; 19843524; 20008553; 20074027; 20508643; 20519439; 20800707; 21139140; 21211719; 21389348; 21427232; 21685082; 21734642; 21931558; 21966278; 22037170; 22086954; 22350874; 22350895; 22460800; 22493437; 22505030; 23102099; 23202731; 23545412; 23644457; 23672618; 23770819; 23965995; 24013205; 24136112; 24598877; 24706844; 25333764; 26130806; 26182356; 26208326; 26262643; 26327695; 26339477; 26344132; 26365526; 26449534; 26642761; 26929360; 27053109; 27432887; 27677933; 28106073; 28115689; 30067984; 30309908; 30792173; 9342402; 9430676; 9584156; 9724628; 9741626; |
| Motif | |
| Gene Encoded By | |
| Mass | 48,828 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 5.6.1.5; |