| IED ID | IndEnz0002008782 |
| Enzyme Type ID | protease008782 |
| Protein Name |
26S proteasome non-ATPase regulatory subunit 14 EC 3.4.19.- 26S proteasome regulatory complex subunit p37B 26S proteasome regulatory subunit rpn11 Yippee-interacting protein 5 |
| Gene Name | Rpn11 yip5 CG18174 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MDRLLRLGGAMPQAAPPTDAPVVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVQVIDVFAMPQTGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINPNMLVLGQEPRQTTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSWKDGLTLSDYNEHCSINEDTVAEMLDLAKNYNKSLEDEEKMTPEQLAIKNVGKQDPKRHLEEKVDKVMQNNIVQCLGAMLDTIVFK |
| Enzyme Length | 308 |
| Uniprot Accession Number | Q9V3H2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.19.- |
| Enzyme Function | FUNCTION: Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). {ECO:0000250, ECO:0000269|PubMed:10893261}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Metal binding (3); Motif (1); Sequence conflict (3) |
| Keywords | Direct protein sequencing;Hydrolase;Metal-binding;Metalloprotease;Protease;Proteasome;Reference proteome;Ubl conjugation pathway;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11945175; 12421421; 12861018; 14605208; 14652013; 14764878; 15735686; 15899868; 16408305; 16652170; 17075830; 17151602; 17344386; 17978103; 18433294; 18519643; 18550751; 19026789; 19075009; 19079254; 19277057; 19529778; 19581588; 20122915; 20220848; 20371351; 20813047; 21074052; 21149573; 21251254; 21319854; 21548953; 22036573; 22197903; 22417167; 22743648; 22884528; 22930061; 22935612; 22937016; 23071443; 23275879; 23291977; 23457214; 23583758; 23738891; 23800266; 23899565; 23999505; 24302569; 24393533; 24681338; 24952591; 25152394; 25294943; 25312911; 25681415; 25776889; 25806519; 26007638; 26159161; 26384358; 26526100; 26551273; 26700685; 26870755; 26917723; 27172210; 27329928; 27471256; 27552662; 27582081; 28633019; 28665616; 28902870; 28916541; 29109084; 29259189; 29427089; 29579685; 29809168; 29855490; 29909722; 30422992; 30816680; 31002009; 31073342; 31080045; 31132524; 31259337; 31320986; 31555733; 31722958; 32573431; 32653676; 33177084; 33242407; 33561251; 33629655; 33988679; 34216545; |
| Motif | MOTIF 111..124; /note=JAMM motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Gene Encoded By | |
| Mass | 34,401 |
| Kinetics | |
| Metal Binding | METAL 111; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 113; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182; METAL 124; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01182 |
| Rhea ID | |
| Cross Reference Brenda | 3.4.25.1; |