IED Industry Enzyme Database

Detail Information for IndEnz0002008784
IED ID IndEnz0002008784
Enzyme Type ID protease008784
Protein Name Protein rhomboid
EC 3.4.21.105
Protein veinlet
Gene Name rho Ve CG1004
Organism Drosophila melanogaster (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly)
Enzyme Sequence MENLTQNVNETKVDLGQEKEKEASQEEEHATAAKETIIDIPAACSSSSNSSSYDTDCSTASSTCCTRQGEHIYMQREAIPATPLPESEDIGLLKYVHRQHWPWFILVISIIEIAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMKSASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIVFNLINTVTAQLMEEQGEVITQHLLHDLGVS
Enzyme Length 355
Uniprot Accession Number P20350
Absorption
Active Site ACT_SITE 217; /note=Nucleophile; /evidence=ECO:0000305|PubMed:11672525; ACT_SITE 281; /evidence=ECO:0000305|PubMed:11672525
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; Evidence={ECO:0000269|PubMed:11672525, ECO:0000269|PubMed:21439629};
DNA Binding
EC Number 3.4.21.105
Enzyme Function FUNCTION: Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor. {ECO:0000269|PubMed:11672525, ECO:0000269|PubMed:21439629}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Compositional bias (1); Mutagenesis (7); Region (1); Sequence conflict (3); Topological domain (8); Transmembrane (7)
Keywords Developmental protein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Serine protease;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10021339; 10072362; 10072780; 10079360; 10087609; 10089881; 10101132; 10102272; 10213677; 10220417; 10225991; 10328928; 10330486; 10331978; 10349622; 10353904; 10357938; 10375505; 10393112; 10402952; 10428032; 10449356; 10457019; 10470647; 10490660; 10502111; 10518987; 10545462; 10556047; 10559873; 10570464; 10572045; 10572049; 10581282; 10588875; 10602463; 10607562; 10625531; 10647930; 10648242; 10652272; 10654600; 10662660; 10684581; 10704397; 10704841; 10704844; 10704851; 10704884; 10742112; 10752030; 10766017; 10769238; 10804180; 10822261; 10835390; 10837029; 10837218; 10842062; 10887086; 10887159; 10889058; 10926773; 10934021; 10952893; 11023685; 11023875; 11051548; 11054563; 11058077; 11063940; 11076763; 11076770; 11099031; 11100709; 11124124; 11128986; 11141565; 11151298; 11171342; 11171397; 11175357; 11223028; 11231065; 11258709; 11260716; 11331590; 11357138; 11369216; 11389437; 11389451; 11389831; 11448630; 11461698; 11483976; 11493599; 11518508; 11525754; 11526075; 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24854999; 24865556; 24896182; 24912777; 24928275; 24961796; 24975577; 24978198; 25006035; 25047722; 25062361; 25155749; 25236355; 25312911; 25328249; 25336739; 25349257; 25421599; 25460353; 25469537; 2558049; 25609699; 25615601; 25679530; 25687947; 25688716; 25748138; 25751057; 25790850; 25813543; 25970241; 26032720; 26042831; 26096970; 26173477; 26214737; 26252385; 26417727; 26633813; 26854918; 26869525; 26896675; 26935860; 26963612; 27038022; 27056762; 27152947; 27293191; 27379389; 27423914; 27501451; 27528688; 27535937; 27662615; 27747375; 27778314; 27974623; 28178204; 28245789; 28246214; 28305338; 28305413; 28305870; 28306126; 28360128; 28406187; 28428262; 28438481; 28535370; 28537903; 28584108; 28628612; 28634244; 28687666; 28701658; 28715417; 28847000; 29196461; 29391183; 29540498; 29567672; 29572440; 29693007; 29723190; 29869981; 29983336; 30065090; 30080872; 30102867; 30142157; 30227165; 30245154; 30252027; 30379844; 30383747; 30389850; 30468713; 30594466; 31006650; 31068592; 31136977; 31439126; 31722958; 31751555; 31941789; 31959292; 32029579; 32060872; 3209069; 32118029; 32143742; 32145545; 32220314; 32243854; 32450970; 32535019; 32539109; 32629605; 32641829; 32894651; 32901612; 32972998; 32980309; 33117802; 33419039; 33666170; 33812867; 33827210; 34107250; 34571929; 34609265; 5519644; 575634; 7552158; 7557390; 7588073; 7601354; 7651519; 7697337; 7720583; 7768193; 7772998; 7774581; 7789267; 7813421; 7833286; 7840966; 7867504; 7883070; 7893745; 7918096; 7925001; 7925025; 7925033; 7937866; 7950316; 7956825; 7956834; 7956840; 7958445; 7958860; 7958919; 8024818; 8026629; 8060613; 8068547; 8076524; 8097144; 8146656; 8162856; 8173320; 8174791; 8178370; 8223245; 8241766; 8241768; 8251016; 8306893; 8307323; 8331336; 8352969; 8370521; 8378299; 8426233; 8453668; 8500182; 8504935; 8521463; 8577836; 8582294; 8598297; 8608867; 8620542; 8625850; 8631502; 8647437; 8670869; 8674429; 8698232; 8742833; 8743887; 8787734; 8790328; 8791421; 8791536; 8825480; 8887317; 8898233; 8913032; 8918893; 8918894; 8951053; 8954716; 8962088; 8988178; 9006064; 9012496; 9012523; 9053303; 9056776; 9056779; 9078426; 9094709; 9102309; 9106165; 9112439; 9154002; 9162494; 9169839; 9171376; 9182755; 9226439; 9262480; 9271119; 9310322; 9326622; 9342046; 9347915; 9363950; 9367424; 9367434; 9367443; 9367733; 9367978; 9392517; 9395407; 9409686; 9428416; 9428420; 9446747; 9472023; 9486793; 9499397; 9550715; 9553046; 9570772; 9570779; 9598357; 9631645; 9637680; 9644838; 9649506; 9654009; 9654017; 9693134; 9693145; 9694625; 9716528; 9729715; 9729726; 9753669; 9753679; 9790523; 9806926; 9811580; 9814698; 9814706; 9817197; 9827802; 9835652; 9866209; 9925640; 9927462; 9927594;
Motif
Gene Encoded By
Mass 39,330
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda