| IED ID | IndEnz0002008787 |
| Enzyme Type ID | protease008787 |
| Protein Name |
Signal transducer and activator of transcription 1-alpha/beta Transcription factor ISGF-3 components p91/p84 |
| Gene Name | STAT1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV |
| Enzyme Length | 750 |
| Uniprot Accession Number | P42224 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed:28753426). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed:26479788). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. {ECO:0000269|PubMed:12764129, ECO:0000269|PubMed:12855578, ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:8156998, ECO:0000269|PubMed:9724754}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Beta strand (19); Chain (1); Coiled coil (1); Cross-link (2); Domain (1); Helix (31); Initiator methionine (1); Modified residue (14); Mutagenesis (19); Natural variant (28); Sequence conflict (3); Turn (7) |
| Keywords | 3D-structure;ADP-ribosylation;Acetylation;Activator;Alternative splicing;Antiviral defense;Coiled coil;Cytoplasm;DNA-binding;Direct protein sequencing;Disease variant;Host-virus interaction;Isopeptide bond;Methylation;Nucleus;Phosphoprotein;Reference proteome;SH2 domain;Transcription;Transcription regulation;Ubl conjugation |
| Interact With | Q16531; O95786; Q01094; P00533; Q8N9N8; P04626; P01100; P17181; P48551; P15260; P23458; P52294; Q7Z434; Q01804; Q05397; P19793; Itself; P52630; P40763; P07239; P0DTC9; Q4VW77; P03255-1; P03255-2; P26664; P27958; P27958; Q9Y4C1; Itself; P06498; Itself |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426}. Nucleus {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. |
| Modified Residue | MOD_RES 2; /note="N-acetylserine"; /evidence="ECO:0007744|PubMed:22223895"; MOD_RES 114; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 175; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 296; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 366; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 525; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 637; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 657; /note="ADP-ribosyl glutamic acid; by PARP14"; /evidence="ECO:0000269|PubMed:27796300"; MOD_RES 665; /note="N6-methyllysine"; /evidence="ECO:0000269|PubMed:28753426"; MOD_RES 701; /note="Phosphotyrosine; by JAK1, JAK2 or TYK2"; /evidence="ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:7657660"; MOD_RES 705; /note="ADP-ribosyl glutamic acid; by PARP14"; /evidence="ECO:0000269|PubMed:27796300"; MOD_RES 708; /note="Phosphoserine; by IKKE"; /evidence="ECO:0000269|PubMed:22065572"; MOD_RES 727; /note="Phosphoserine; by MAPK14"; /evidence="ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:17897103, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:7543024, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163"; MOD_RES 745; /note="Phosphoserine; by IKKE"; /evidence="ECO:0000250|UniProtKB:P42225" |
| Post Translational Modification | PTM: Phosphorylated on tyrosine and serine residues in response to a variety of cytokines/growth hormones including IFN-alpha, IFN-gamma, PDGF and EGF. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Upon EGF stimulation, phosphorylation on Tyr-701 (lacking in beta form) by JAK1, JAK2 or TYK2 promotes dimerization and subsequent translocation to the nucleus. Growth hormone (GH) activates STAT1 signaling only via JAK2. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylation on Ser-727 by several kinases including MAPK14, ERK1/2 and CAMKII on IFN-gamma stimulation, regulates STAT1 transcriptional activity. Phosphorylation on Ser-727 promotes sumoylation though increasing interaction with PIAS. Phosphorylation on Ser-727 by PRKCD induces apoptosis in response to DNA-damaging agents. Phosphorylated on tyrosine residues when PTK2/FAK1 is activated; most likely this is catalyzed by a SRC family kinase. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates interferon-mediated signaling. Upon viral infection or IFN induction, phosphorylation on Ser-708 occurs much later than phosphorylation on Tyr-701 and is required for the binding of ISGF3 on the ISREs of a subset of IFN-stimulated genes IKBKE-dependent. Phosphorylation at Tyr-701 and Ser-708 are mutually exclusive, phosphorylation at Ser-708 requires previous dephosphorylation of Tyr-701. {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:17897103, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426, ECO:0000269|PubMed:7543024, ECO:0000269|PubMed:7657660}.; PTM: Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation is enhanced by IFN-gamma-induced phosphorylation on Ser-727, and by interaction with PIAS proteins. Enhances the transactivation activity. {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:17897103, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:22065572, ECO:0000269|PubMed:7543024}.; PTM: ISGylated. {ECO:0000269|PubMed:16139798}.; PTM: Mono-ADP-ribosylated at Glu-657 and Glu-705 by PARP14; ADP-ribosylation prevents phosphorylation at Tyr-701 (PubMed:27796300). However, the role of ADP-ribosylation in the prevention of phosphorylation has been called into question and the lack of phosphorylation may be due to sumoylation of Lys-703 (PubMed:29858569). {ECO:0000269|PubMed:27796300, ECO:0000305|PubMed:29858569}.; PTM: Monomethylated at Lys-525 by SETD2; monomethylation is necessary for phosphorylation at Tyr-701, translocation into the nucleus and activation of the antiviral defense. {ECO:0000269|PubMed:28753426}.; PTM: (Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22. {ECO:0000269|PubMed:32699158}. |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (1); X-ray crystallography (4) |
| Cross Reference PDB | 1BF5; 1YVL; 2KA6; 3WWT; 7NUF; |
| Mapped Pubmed ID | 10022928; 10329697; 10329948; 10358045; 10359822; 10383940; 10453004; 10523304; 10542198; 10562299; 10570180; 10645003; 10748192; 10753717; 10805787; 10820245; 10820262; 10821852; 10851062; 10878008; 10918585; 10918587; 10918594; 10919676; 10940874; 10982844; 11023524; 11092454; 11238845; 11306517; 11309387; 11337497; 11369651; 11404376; 11418623; 11438544; 11494148; 11641425; 11675348; 11689702; 11752148; 11777927; 11788588; 11804954; 11815625; 11835405; 11839738; 11843291; 11866432; 11884587; 11886239; 11886859; 11909529; 11909852; 11909970; 11932384; 11971902; 11972023; 11981818; 12023369; 12029096; 12040185; 12048190; 12068083; 12070153; 12093291; 12130529; 12161037; 12165521; 12171910; 12191570; 12223098; 12232043; 12232802; 12244150; 12270932; 12351624; 12386158; 12388709; 12447867; 12459177; 12481435; 12517932; 12522257; 12526087; 12551969; 12582176; 12610144; 12629155; 12634403; 12637327; 12722480; 12748293; 12759242; 12759422; 12766484; 12777975; 12788789; 12799548; 12804067; 12804771; 12807916; 12811837; 1281555; 12817007; 12832402; 12846741; 12855573; 12856330; 12883649; 12915721; 12917439; 12923053; 12923054; 12948935; 12963127; 12967644; 12971583; 14500749; 14557668; 14565860; 14599788; 14600148; 14623896; 14648593; 14654702; 14656722; 14657353; 14688135; 14690454; 14712222; 14742442; 14746803; 14751560; 14755057; 14764663; 14769151; 14963018; 14976049; 14978237; 15007386; 15010467; 15047845; 15055356; 1508672; 15123634; 15165826; 15182726; 15210729; 15213094; 15217838; 15221897; 15261459; 15280488; 15284024; 15297606; 15320963; 15527154; 15585657; 15604419; 15650219; 15671148; 15695932; 15728510; 15778351; 15780933; 15790786; 15795279; 15850832; 15950906; 15979846; 15994321; 15994429; 15996661; 15998520; 16007214; 16009940; 16059651; 16077199; 16148108; 16148142; 16189514; 16195225; 16204068; 16223733; 16254375; 16257975; 16260419; 16273093; 16314732; 16318585; 16324217; 16343349; 16388135; 16418217; 16464493; 16467883; 16481475; 16501077; 16511123; 16512786; 16516295; 16571725; 16572323; 16574066; 16585190; 16628196; 16729885; 16773129; 16799645; 16878149; 16897667; 16904741; 16918696; 16935931; 16940534; 16951379; 16978698; 17030574; 17066093; 17072862; 17075845; 17145596; 17182865; 17196131; 17227821; 17237409; 17258468; 17266440; 17275127; 17277783; 17287281; 17293456; 1730654; 17325127; 17346710; 17351669; 17353931; 17371985; 17383622; 17386941; 17427945; 17442890; 17486072; 17488182; 17490620; 17523873; 17525742; 17538964; 17546049; 17565448; 17579625; 17596301; 17617740; 17620599; 17622177; 17640695; 17680769; 17686504; 17696225; 17703412; 17726060; 17785551; 17785783; 17804871; 17878351; 17879956; 17909067; 17918184; 17923090; 17928350; 17933493; 17938255; 17983380; 17986321; 18003888; 18031232; 18035482; 18062835; 18190974; 18218993; 18225539; 18267069; 18280748; 18292512; 18305014; 18305569; 18338947; 18348986; 18362138; 18370868; 18378670; 18381204; 18389480; 18401423; 18424756; 18463151; 18483262; 18500930; 18508557; 18566411; 18574148; 18575461; 18579584; 18579593; 18586252; 18591661; 18633131; 18660489; 18676680; 18771758; 18782771; 18787082; 18787531; 18789440; 18803832; 18817573; 18818378; 18830264; 18832710; 18941194; 18941537; 18950845; 1898761; 18989459; 19007958; 19012493; 1901265; 19017763; 19041714; 19046253; 19052084; 19074829; 19100922; 19124747; 19170196; 19171783; 19174562; 19211553; 19214187; 19223260; 19231233; 19258923; 19333953; 19342095; 19349465; 19351818; 19367337; 19367725; 19393742; 19396596; 19397496; 19397895; 19404407; 19423540; 19424608; 19434718; 19436109; 19437244; 19439556; 19453261; 19464956; 19478064; 19502801; 19508864; 19515782; 19535621; 19551150; 19553685; 19561067; 19574556; 19582813; 19594299; 19596857; 19604093; 19622834; 19625176; 19646959; 19656875; 19667270; 19691533; 19692168; 19781967; 19801665; 19802007; 19846878; 19857525; 19891767; 19913121; 19915063; 19915608; 19935876; 20006573; 20011528; 20045654; 20065083; 20093796; 20098684; 20103601; 20169197; 20180146; 20195357; 20225206; 20331378; 20345984; 20347693; 20353823; 20403236; 20406964; 20428775; 20438785; 20457620; 20493732; 20503287; 20504369; 20519510; 20523058; 20562129; 20568281; 20576130; 20588308; 20624457; 20628086; 20628624; 20643137; 20662656; 20675591; 20711500; 20738848; 20798561; 20802378; 20810735; 20814891; 20829351; 20832538; 20833730; 20936779; 20937132; 20949125; 20974954; 20974984; 20980339; 21056555; 21057861; 21084836; 21091911; 21106534; 21115047; 21189227; 21207025; 21288140; 21303487; 21307288; 21311224; 21321110; 21345084; 21346151; 21351482; 21354905; 21362620; 21368418; 21372127; 21466707; 21477834; 21533215; 21545749; 21571862; 21572044; 21593149; 21654841; 21674123; 21690236; 21697347; 21734056; 21752694; 21772053; 21776018; 21783819; 21795355; 21796151; 21878628; 21903422; 21911578; 21937440; 21937453; 21968657; 21988832; 21992896; 21999474; 22002246; 22022391; 22025054; 22038351; 22038826; 22089421; 22110204; 22115721; 2211721; 22126015; 22174846; 22178447; 22193460; 22194871; 22217266; 22242177; 22253910; 22262126; 22306001; 22306691; 22320867; 22326919; 22348975; 22355301; 22381273; 22383755; 22401175; 22425562; 22435755; 22437822; 22479354; 22488367; 22514085; 22526675; 22527947; 22535619; 22539792; 22558273; 22674974; 22693070; 22730530; 22748021; 22748593; 22788969; 22805310; 22808166; 22810585; 22811740; 22814351; 22823229; 22828446; 22838736; 22844427; 22920439; 22920460; 22942432; 22973045; 22996189; 23013371; 23043228; 23068100; 23072252; 23073628; 23076242; 23086340; 23108375; 23121362; 23124025; 23153456; 23154639; 23174178; 23178573; 23180800; 23221969; 23240025; 23245396; 23257612; 23271704; 23274199; 23306614; 23349666; 23352233; 23378427; 23386060; 23386615; 23397142; 23401241; 23403048; 23416715; 23440042; 23449448; 23452095; 23455323; 23471820; 23472246; 23486482; 23487038; 23534974; 23541320; 23554911; 23580655; 23582260; 23585528; 23585529; 23588992; 23597922; 23609054; 23621408; 23633948; 23637938; 23703473; 23704922; 23708675; 23741352; 23752188; 23756862; 23760261; 23796786; 23825585; 23845085; 23856440; 23890093; 23910645; 23917221; 23917355; 23920124; 23922848; 23940278; 23941832; 23943785; 23950992; 23958647; 23984931; 24014650; 24037089; 24058793; 24065129; 24069555; 24086752; 24131713; 24166946; 24188975; 24220695; 24239102; 24255956; 24292724; 24319264; 24343863; 24360797; 24449862; 24451065; 24454965; 24478085; 24572363; 24626739; 24646078; 24658140; 24658320; 24681956; 24693969; 24699362; 24715035; 24725474; 24728078; 24743305; 24743777; 24769842; 24788809; 24810717; 24814927; 24821973; 24825907; 24838635; 24847715; 24858600; 24878287; 24886089; 24894488; 24911872; 24931237; 24975396; 25040843; 25042743; 25056900; 25104439; 25113744; 25170834; 25205818; 25226283; 25241761; 25267067; 25271420; 25293394; 25297818; 25303530; 25311665; 25340519; 25355139; 25416956; 25417103; 25438156; 25474274; 25478796; 25526807; 25535969; 25589644; 25605239; 25609649; 25686822; 25690042; 25707685; 25753288; 25771902; 25773877; 25814554; 25818476; 25847223; 25858560; 25865496; 25880788; 25905045; 25921060; 25941617; 25950470; 25959715; 25965795; 25972070; 25992861; 25995822; 26025667; 26028607; 26080282; 26113305; 26119280; 26141950; 26153763; 26155422; 26156524; 26193702; 26232434; 26238487; 26242181; 26255980; 26265185; 26275341; 26335850; 26339056; 26351076; 26353965; 26362649; 26396258; 26397446; 26401035; 26413796; 26467763; 26495772; 26496208; 26504087; 26560068; 26592235; 26604104; 26635038; 26676749; 26676844; 26678048; 26709547; 26719274; 26735690; 26743090; 26747737; 26774166; 26783516; 26795953; 26839680; 26901336; 26928402; 26931423; 26966684; 26996068; 27074819; 27080594; 27137788; 27153543; 27170215; 27191495; 27213290; 27220814; 27227879; 27228072; 27301951; 27304884; 27350337; 27379765; 27386938; 27387064; 27412544; 27422384; 27434509; 27437406; 27457515; 27464833; 27470968; 27486982; 27512950; 27581546; 27617644; 27705947; 27715403; 27769057; 27774606; 27781323; 27791205; 27808400; 27819281; 27820940; 27825967; 27855377; 27855602; 27856304; 27893714; 27913706; 27929099; 27965977; 27992555; 28039018; 28059079; 28069426; 28086195; 28108623; 28112370; 28142265; 28150292; 28161409; 28186502; 28192400; 28256939; 28258222; 28262979; 28273453; 28274199; 28322462; 28334721; 28359509; 28391993; 28403213; 28407302; 28411130; 28422713; 28430601; 28431406; 28432122; 28432285; 28447741; 28471454; 28510715; 28542650; 28550731; 28552376; 28560754; 28578326; 28593745; 28601685; 28622443; 28649004; 28671669; 28676732; 28739485; 28819304; 28859974; 28865492; 28914637; 28922548; 28978648; 28981100; 29021395; 29054602; 29079187; 29150430; 29176033; 29234062; 29239838; 29270166; 29303938; 29328389; 29348488; 29371942; 29374380; 29391602; 29394132; 29417241; 29474442; 29510136; 29530483; 29540832; 29604049; 29620180; 29651441; 29686406; 29691476; 29715456; 29729381; 29739101; 29751820; 29796172; 29800921; 29855346; 29859868; 29893425; 29901104; 29925658; 29925830; 29930380; 29946223; 29964125; 30007645; 30018336; 30030262; 30131584; 30150992; 30226605; 30280610; 30317461; 30323286; 30334368; 30373602; 30374200; 30389923; 30410131; 30412483; 30455980; 30456450; 30478987; 30485383; 30506884; 30543054; 30588194; 30619249; 30655323; 30674474; 30679801; 30687322; 30842274; 30878028; 30886199; 30936295; 30940163; 30952894; 30967527; 30993511; 31081058; 31085626; 31108008; 31113461; 31196219; 31202985; 31205408; 31216116; 31228268; 31230364; 31242951; 31248982; 31263070; 31318097; 31336247; 31352002; 31375561; 31408005; 31440940; 31493649; 31513548; 31548239; 31552016; 31605752; 31653890; 31686315; 31709529; 31774398; 31804622; 31827061; 31840082; 31846457; 31867619; 31918717; 31948748; 31974171; 32006593; 32032660; 32036580; 32037480; 32048448; 32108380; 32123171; 32181805; 32183180; 32196427; 32209697; 32260399; 32275681; 32284404; 32286295; 32292520; 32319563; 32329850; 32330348; 32357246; 32390230; 32396871; 32401659; 32420725; 32516753; 32526033; 32549769; 32552942; 32582194; 32603428; 32606936; 32642677; 32661180; 32673428; 32696599; 32755630; 32761670; 32792604; 32803897; 32831137; 32852681; 32864202; 32938761; 32950480; 32951108; 32964981; 32981207; 32985214; 32987855; 33020563; 33043814; 33096415; 33099760; 33127822; 33207265; 33208444; 33220929; 33238771; 33242255; 33260038; 33290632; 33361763; 33387041; 33389635; 33391546; 33454903; 33475942; 33486325; 33497867; 33504682; 33519429; 33529688; 33644712; 33652086; 33664283; 33679782; 33692335; 33712566; 33734579; 33741434; 33747209; 33753770; 33759138; 33777053; 33779079; 33798037; 33815425; 33976173; 33979266; 34021047; 34092011; 34114647; 34224325; 34283251; 34333925; 34421897; 34516357; 34649540; 34676541; 34687317; 34710525; 34773335; 34935627; 34943910; 6162102; 6548414; 7504784; 7510216; 7512451; 7521688; 7530745; 7537377; 7540766; 7579336; 7592750; 7690989; 7701321; 7775604; 7796299; 8140422; 8176225; 8232552; 8483949; 8523587; 8530158; 8608222; 8621447; 8631301; 8657151; 8662591; 8662795; 8732683; 8756628; 8830676; 8900180; 8940092; 8977235; 9096384; 9143706; 9202127; 9226159; 9242679; 9353323; 9355737; 9399961; 9484840; 9535918; 9649436; 9739761; 9861020; 9862674; 9864141; 9864153; 9881977; |
| Motif | |
| Gene Encoded By | |
| Mass | 87,335 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |