| IED ID | IndEnz0002008818 |
| Enzyme Type ID | protease008818 |
| Protein Name |
Sentrin-specific protease 7 EC 3.4.22.- SUMO-1-specific protease 2 Sentrin/SUMO-specific protease SENP7 |
| Gene Name | SENP7 SUSP2 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MDKGKAGRRRSSAEIVTEGKRKKPSSSELHKITKILNAKPEDVHVQSPLSKLRSSEHWDVSLQGWKRSLRNKVLSLDHKSKKGVRGHPVTSKISPERQLKVMLTNVLWTDLGRKFRKTLPRNDANLCDANKVQSDSLPSTSVDSLETCQKLEPLHQSLNLSERIPRVILTNVLGTKLGRKYIKTSSVTEANLGDTDNLQSEQLSSSSDGSLESCQNLNPHKNFFLSESSSQSSKTDNYAKQTSYTKEKRRDDDGISFMSDTQPKDLSSGSRDCDHLEVGSRNKDDTNSVSRMEPTLISRKRKKRLRSNLPDTHNPASLYKSAEQTKEQENDPAVFTELEKSSENYHEDPKLFEEVTYESIESDFAQLPSDCGQELALSASPQMTSGCSAMETFESSISSDTVGNSTLVVKDENELNTIEKPVLSEHSEGNLSFISAEPIVVSSDEEGPTEQKSSEILKLQPKQDDAISHESESTSEPVVSELPLITCESVQTSSELCSYNPVMENISCLIPKNEMDLQLDFIFTSVYIGKIKGASKGCVTFTTKYIKIPFQVSVHEISLLVDTTHLKRFGLWKNKDDDHSKKSHAILFLWVSSNYLQEIQTQLENSVFSQQSKSTEFIFLELHSSISQREELKLKDIMTEISTTNGELELSYPLSWVQALPLFQNLSSKESSFIHYYCASTCSFPAATTEEMKMKSVSQPSNTDTAKPTYTLLQKQSSGCYSLSITSNPDEEWREVRHTGPVQKLIVYPPPPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLILEKASDELVERSHIFSSFFYKCLTRKENNLTEDNPNLSMAQRRHKRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFPWLEEVVYEDFPQTIPQYSQAEESHHDSRTIDNDLHTSSALSSGTEDSQSPEMNVTVPKKMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESFFKDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQQQKGSSS |
| Enzyme Length | 1047 |
| Uniprot Accession Number | A7MBJ2 |
| Absorption | |
| Active Site | ACT_SITE 857; /evidence=ECO:0000250|UniProtKB:Q9HC62; ACT_SITE 936; /evidence=ECO:0000250|UniProtKB:Q9HC62; ACT_SITE 989; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:Q9HC62 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity). {ECO:0000250|UniProtKB:Q8BUH8, ECO:0000250|UniProtKB:Q9BQF6}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (5); Modified residue (6); Region (5) |
| Keywords | Cytoplasm;Hydrolase;Immunity;Innate immunity;Phosphoprotein;Protease;Reference proteome;Thiol protease;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BUH8}. |
| Modified Residue | MOD_RES 11; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BQF6; MOD_RES 12; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8BUH8; MOD_RES 25; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BQF6; MOD_RES 432; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BQF6; MOD_RES 442; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BQF6; MOD_RES 443; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9BQF6 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 118,889 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |