| IED ID | IndEnz0002008878 |
| Enzyme Type ID | protease008878 |
| Protein Name |
Presenilins-associated rhomboid-like protein, mitochondrial EC 3.4.21.105 |
| Gene Name | parl zgc:112986 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MAWRSCFMKWTQINSINASSLCPKSTRLNIHPQQRCGFRKTERPSESKKGVQETEAEAGGHNRAVPPKPVPPLPPRRPHQLFRPLVFTVGFTGCSFGAAAILQYESVKSRVQLAIEEAKEEKRDTLLEGHDTTYWHNWWNQLSNFQKQVILLISAVDDFWSGLSEGQKTVTGIIALNTVVLCCWRVPAMQRFLVKYFTSNPASKTRCLPMVLSSFSHYSVIHMVVNMYVLWTFSSSIVSLLGREQFLALYLSGGVISTFVSYVFKTATGRLGPSLGASGSIMTVLAAVCTKIPEAKLGIVLLPVISFSAGNALKALVALDIAGLVLGWRFFDHAAHLGGALFGVWYIGYGHELIWRKREPLIKFWHELRNMSPGRPGPGGGGG |
| Enzyme Length | 383 |
| Uniprot Accession Number | Q58EK4 |
| Absorption | |
| Active Site | ACT_SITE 278; /note=Nucleophile; /evidence=ECO:0000250; ACT_SITE 336; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.; EC=3.4.21.105; |
| DNA Binding | |
| EC Number | 3.4.21.105 |
| Enzyme Function | FUNCTION: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of opa1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Compositional bias (1); Region (1); Topological domain (8); Transit peptide (1); Transmembrane (7) |
| Keywords | Hydrolase;Membrane;Mitochondrion;Mitochondrion inner membrane;Protease;Reference proteome;Serine protease;Transit peptide;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9H300}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H300}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22506991; |
| Motif | |
| Gene Encoded By | |
| Mass | 42,409 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |